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Community-Led Regeneration

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ISBN: 9781787356061 Year: Pages: 184 DOI: 10.14324/111.9781787356061 Language: English
Publisher: UCL Press
Subject: Social Sciences
Added to DOAB on : 2020-05-06 07:12:59
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Through seven London case studies of communities opposing social housing demolition and/or proposing community-led plans, Community-Led Regeneration offers a toolkit of planning mechanisms and other strategies that residents and planners working with communities can use to resist demolition and propose community-led schemes. The case studies are Walterton and Elgins Community Homes, West Ken and Gibbs Green Community Homes, Cressingham Gardens Community, Greater Carpenters Neighbourhood Forum, Focus E15, People’s Empowerment Alliance for Custom House (PEACH), and Alexandra and Ainsworth Estates. Together, these case studies represent a broad overview of groups that formed as a reaction to proposed demolitions of residents' housing, and groups that formed as a way to manage residents' homes and public space better.

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housing --- community --- regeneration --- London

Sheffield Castle

Authors: ---
ISBN: 9781912482290 Year: Pages: 404 DOI: 10.22599/SheffieldCastle Language: English
Publisher: White Rose University Press
Subject: Archaeology --- Architecture
Added to DOAB on : 2020-09-23 00:07:17
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"Sheffield Castle presents an original perspective on an urban castle, resurrecting from museum archives a building that once made Sheffield a nexus of power in medieval England, its lords playing important roles in local, national, and international affairs. Although largely demolished at the end of the English Civil War, the castle has left an enduring sway over the present townscape, and future development, of Sheffield. In this volume, we rediscover the medieval castle, explore its afterlife, and discuss its legacy for the regeneration of Sheffield into the twenty-first century. The authors bring to publication for the first time all the major excavations on the site, present the first modern study of artefacts excavated in the mid-twentieth century, and situate both in the context of the published and unpublished documentary record. They also tell the stories of those responsible for re-discovering the castle, the circumstances in which they were working, their archaeological methods, and the scholarly and political influences that shaped their narratives. In setting the study within the context of urban regeneration, Sheffield Castle differs from most publications of medieval castles. This regeneration narrative is both historical, addressing the ways in which successive building campaigns have encountered the castle remains, and current, as the future of the site is under active discussion following the demolition of the market hall built on the site in the 1960s. The book explores how the former existence of the castle, and the landscape in which it sat, including its deer park, have shaped the development of the ‘Steel City’. We see that the untapped heritage of the site has considerable value for the regeneration of what may now be one of the most deprived areas of Sheffield, but was once at its social, political and cultural heart. Prof John Moreland (University of Sheffield) and Prof Dawn Hadley (now University of York) led the University of Sheffield’s Sheffield Castle project, and worked with colleagues from Wessex Archaeology, Museums Sheffield and the contributors named below. This volume, written with Ashley Tuck and Milica Rajic from Wessex Archaeology, presents the culmination of the findings of this project and is, importantly, accompanied by a digital archive, making all the research materials publicly available. "

Myelin-Mediated Inhibition of Axonal Regeneration: Past, Present, and Future

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452064 Year: Pages: 116 DOI: 10.3389/978-2-88945-206-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-10-13 14:57:01
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Pioneering studies conducted in the 1980’s laid the foundation for the hypothesis that axonal regeneration is limited by CNS myelin, and the identification of myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein (OMgp) as inhibitors of neurite outgrowth firmly established myelin as a key factor in regenerative failure. Mechanistically, it has been shown that MAG, Nogo, and OMgp mediate inhibition by binding to either Nogo receptor (NgR) or paired immunoglobulin receptor B (PirB), and initiating a signaling cascade that culminates in the activation of RhoA.Since the discovery of these proteins, there has been tremendous interest in identifying compounds and molecular mechanisms that are capable of overcoming myelin-mediated inhibition. Many studies have focused on pharmacological antagonism of receptors and signaling intermediates, while others have sought to identify and enhance endogenous pro-regenerative pathways. The most notable example of the latter is the conditioning lesion effect, which led to the discovery of cyclic AMP’s ability to overcome inhibition by MAG and myelin. Many of the agents tested in these studies have been shown to promote axonal regeneration in vivo, and this research topic allows researchers to share information about new treatments that have been developed in both academia and industry. As we look toward the future, it is becoming increasingly clear that reversal of myelin-mediated inhibition alone will not be sufficient to produce functional recovery from spinal cord injury, and that other factors, such as astroglial scarring, the expression of chondroitin sulfate proteoglycans, neuronal cell death, and lack of neurotrophic support, must also be taken into consideration. Combinatorial approaches therefore hold a great deal of promise, and we hope to initiate a dialogue on how stem cell transplantation, chondroitinase ABC, gene therapy, growth-promoting agents, and other methods can be combined to optimize functional recovery. We introduce this topic in honor of the life and work of Dr. Marie T. Filbin (1955-2014). Through these articles, we highlight past achievements in the field, novel findings, unanswered questions and innovative ideas that we hope will lead to new advances in axonal regeneration.

Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198320 Year: Pages: 259 DOI: 10.3389/978-2-88919-832-0 Language: English
Publisher: Frontiers Media SA
Subject: Physiology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field.

Inorganic Biomaterials

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198016 Year: Pages: 149 DOI: 10.3389/978-2-88919-801-6 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering --- Materials --- Biotechnology
Added to DOAB on : 2016-04-07 11:22:02
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The intention of the editors A. R. Boccaccini and W. Höland has been to target this e-book to a broad readership and at the same time to present scientific contributions sufficiently detailed which discuss various specific fundamental aspects of inorganic biomaterials and their biomedical and dental applications. In this context, two large categories of biomaterials need to be mentioned, namely bioactive biomaterials for the replacement and regeneration of hard tissue and biocompatible, non-bioactive biomaterials for restorative dentistry. Both categories include products based on glasses or glass-ceramics as well as organic-inorganic composite materials. Among the bioactive products, BIOGLASS®, developed in the late 1960s by Prof. Dr. L. L. Hench, occupies a prominent position, being BIOGLASS® the first man-made material shown to form strong and functional bonding to leaving tissue. Sadly, Prof. Hench passed away in December 2015, at the time this e-book was being completed, it is therefore a great honor for the editors to dedicate this e-book to his memory. Indeed the book contains a comprehensive review written by Prof. Hench, in collaboration with Prof. J. R. Jones (UK), which provides a timely overview of the development and applications of bioactive glasses, including a discussion on the remaining challenges in the field. Further bioactive materials have been developed over the years by leading scientists such as Prof. Kokubo (Japan). These materials have also found their way into this book. The other contributions in this book, written by worldwide recognized experts in the field, present the latest advances in relevant areas such as scaffolds for bone tissue engineering, metallic ion releasing systems, cements, bioactive glass–polymer coatings, composites for bone regeneration, and effect of porosity on cellular response to bioceramics. In addition to bioactive materials, inorganic systems for restorative dentistry are also discussed in this e-book. Biomaterials for dental restorations consist of glassy or crystalline phases. Glass-ceramics represent a special group of inorganic biomaterials for dental restorations. Glass-ceramics are composed of at least one inorganic glassy phase and at least one crystalline phase. These products demonstrate a combination of properties, which include excellent aesthetics and the ability to mimic the optical properties of natural teeth, as well as high strength and toughness. They can be processed using special processing procedures, e.g. machining, moulding and sintering, to fabricate high quality products. The editors would like to extend their gratitude to the Frontiers team in Lausanne, Switzerland, for their outstanding dedication to make possible the publication of this e-book in a timely manner. It is our wish that the book will contribute to expand the field of inorganic biomaterials, both in terms of fundamental knowledge and applications, and that the book will be useful not only to established researchers but also to the increasing number of young scientists starting their careers in the field of inorganic biomaterials.

Migrants and City-Making

Authors: ---
ISBN: 9780822370444 9780822372011 Year: Language: English
Publisher: Duke University Press Grant: Knowledge Unlatched - 102064
Subject: Sociology
Added to DOAB on : 2019-03-08 11:21:03
License: Duke University Press

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In Migrants and City-Making Ayşe Çağlar and Nina Glick Schiller trace the participation of migrants in the unequal networks of power that connect their lives to regional, national, and global institutions. Grounding their work in comparative ethnographies of three cities struggling to regain their former standing — Mardin, Turkey; Manchester, New Hampshire; and Halle/Saale, Germany — Çağlar and Glick Schiller challenge common assumptions that migrants exist on society’s periphery, threaten social cohesion, and require integration. Instead Çağlar and Glick Schiller explore their multifaceted role as city-makers, including their relationships to municipal officials, urban developers, political leaders, business owners, community organizers, and social justice movements.

Advances in Catalyst Deactivation

Authors: ---
ISBN: 9783038421870 9783038421887 Year: Pages: X, 300 DOI: 10.3390/books978-3-03842-188-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemical Engineering
Added to DOAB on : 2016-06-07 11:25:06
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Catalyst deactivation, the loss over time of catalytic activity and/or selectivity, is a problem of great and continuing concern in the practice of industrial catalytic processes. Costs to industry for catalyst replacement and process shutdown total tens of billions of dollars per year. While catalyst deactivation is inevitable for most processes, some of its immediate, drastic consequences may be avoided, postponed, or even reversed. Accordingly, there is considerable motivation to better understand catalyst decay and regeneration. Indeed, the science of catalyst deactivation and regeneration has been developing rapidly as evidenced by the considerable literature addressing this topic, including 21,000 journal articles, presentations, reports, reviews, and books; and more than 29,000 patents for the period of 1980 to 2012. This developing science provides the foundation for continuing, substantial improvements in the efficiency and economics of catalytic processes through development of catalyst deactivation models, more stable catalysts, and regeneration processes.This special issue focuses on recent advances in catalyst deactivation and regeneration, including advances in (1) scientific understanding of mechanisms; (2) development of improved methods and tools for investigation; and (3) more robust models of deactivation and regeneration.

The CERN Resonant WISP Search (CROWS)

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Book Series: Karlsruher Forschungsberichte aus dem Institut für Hochleistungsimpuls- und Mikrowellentechnik ISSN: 21922764 ISBN: 9783731501992 Year: Volume: 5 Pages: XIV, 183 p. DOI: 10.5445/KSP/1000039767 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:01
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The subject of this work is the design, implementation and first results of the ""CERN Resonant WISP Search"" (CROWS), which probes the existence of Axion Like Particles and Hidden Sector Photons (HSPs) using microwave techniques. By exploiting low loss cavity resonators, multiple layers of electromagnetic shielding and a micro-Hz bandwidth detection scheme, new exclusion limits could be set. For HSPs, sensitivity was improved by a factor of ~7 compared to previous laboratory experiments.

Sensory Hair Cell Death and Regeneration

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450008 Year: Pages: 266 DOI: 10.3389/978-2-88945-000-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.

Karolinska Institutet 200-Year Anniversary Symposium on Injuries to the Spinal Cord and Peripheral Nervous System - An Update on Recent Advances in Regenerative Neuroscience

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453245 Year: Pages: 74 DOI: 10.3389/978-2-88945-324-5 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2018-02-27 16:16:45
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The present E-book consists of original articles and reviews published in our Research Topic on injuries to the spinal cord and peripheral nerves and presents a wide array of novel findings and in depth discussions on topics within the field of nerve injury and repair. Our aim with this Research Topic is to bring together knowledge spanning from basic laboratory studies to clinical findings and strategies within the field of spinal cord and nerve injury and repair. We hope this publication will provide a basis for accelerated knowledge exchange within the field and hopefully a subsequent increase in research efforts and collaborations.

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