Search results: Found 5

Listing 1 - 5 of 5
Sort by
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198665 Year: Pages: 220 DOI: 10.3389/978-2-88919-866-5 Language: English
Publisher: Frontiers Media SA
Subject: Biology --- Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.

Aging and Age-related Disorders: From Molecular Mechanisms to Therapies

Author:
ISBN: 9783039213559 / 9783039213566 Year: Pages: 322 DOI: 10.3390/books978-3-03921-356-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.

Environment-Friendly Construction Materials

Authors: --- --- ---
ISBN: 9783039210121 / 9783039210138 Year: Pages: 280 DOI: 10.3390/books978-3-03921-013-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-06-26 08:44:06
License:

Loading...
Export citation

Choose an application

Abstract

Construction materials are the most widely used materials for civil infrastructure in our daily lives. However, from an environmental point of view, they consume a huge amount of natural resources and generate the majority of greenhouse gasses. Therefore, many new and novel technologies for designing environmentally friendly construction materials have been developed recently. This Special Issue, “Environment-Friendly Construction Materials”, has been proposed and organized as a means to present recent developments in the field of construction materials. It covers a wide range of selected topics on construction materials.

Keywords

Ca-alginate microcapsules --- microfluidic --- self-healing --- bitumen --- mineral-asphalt mixtures --- aggregate from sanitary ceramic wastes --- environmentally friendly construction materials --- diatomite --- styrene–butadiene–styrene (SBS) modified bitumen --- diatomite-modified asphalt mixture --- road engineering --- fatigue life --- three-point bending fatigue test --- asphalt mixture --- plateau value of permanent deformation ratio --- damage evolution --- fatigue equation --- ultraviolet radiation --- bitumen --- aging depth --- transmittance --- permeation --- expanded graphite --- polyethylene glycol --- phase change materials --- titanate coupling agent --- molecular bridge --- building envelopes --- thermal property --- building energy conservation --- reclaimed asphalt pavement --- recycling --- epoxidized soybean oil --- rejuvenator --- diffusing --- asphalt pavement --- fatigue property --- pavement failure --- long-term field service --- asphalt mixture --- microwave heating --- induction heating --- effective heating depth --- induced healing --- initial self-healing temperature --- asphalt mastic --- flow behavior index --- steel slag --- limestone --- aggregate morphology --- aggregate image measurement system --- micro-surfacing --- skid-resistance --- surface texture --- asphalt --- water solute exposure --- aqueous solute compositions --- chemical evolutions --- rheological properties --- polyacrylic acid --- fluidity --- rheology --- adsorption --- combination --- cement emulsified asphalt mixture --- fatigue performance --- thickness combinations --- X-ray computed tomography --- artificial neural network --- crumb rubber --- high-strength concrete --- damping --- dynamic moduli --- railway application --- recycled material --- recycling --- sanitary ceramics --- concrete --- recycling aggregate --- asphalt mixture --- basalt fiber --- response surface methodology --- design optimization --- fluorescence spectrum --- bitumen --- ageing --- parametrization --- “blue-shift” --- asphalt --- asphalt mortar --- healing agents --- crack healing --- healing model --- ultra-thin wearing course --- self-healing --- induction heating --- steel fiber --- steel slag --- rankinite --- carbonation --- waste concrete --- CO2 --- aged bitumen --- rejuvenator --- solubilizer --- colloidal structure --- micro-morphology --- granite aggregate --- desulphurization gypsum residues --- rubber modified asphalt --- asphalt mixture --- pavement performance --- limestone aggregates --- emulsified asphalt --- demulsification speed --- surface energy --- specific surface area --- artificially aged asphalt mixture --- rejuvenator --- durability --- dynamic characteristics --- overlay tester --- energy-based approach --- dissipated strain energy --- plateau value of dissipated strain energy ratio --- fatigue life --- three-point bending fatigue test --- amorphous silica --- crystallization sensitivity --- water-leaching pretreatment --- rice husk ash --- cement --- crumb rubber --- anti-rutting agent --- flexibility --- field evaluation --- asphalt mixes --- aggregate characteristics --- simplex lattice design --- viscoelastic properties --- asphalt combustion --- flame retardant --- aluminum hydroxide --- layered double hydroxide --- asphalt mixture --- viscoelastic properties --- creep --- relaxation --- aggregates --- morphology --- crumb rubber powder --- SBS/CRP-modified bitumen --- aging processes --- temperature sensitivity characteristics --- diatomite --- basalt fiber --- asphalt mixture --- low-temperature --- damage constitutive model --- graphene --- nitrogen and phosphorus removal --- MDA --- SOD --- sequencing batch Chlorella reactor --- SEM --- thermal–mechanical properties --- bio-oil --- regeneration --- aged asphalt --- molecular dynamic simulation --- viscoelasticity --- nanomaterial --- hydrophobic nanosilica --- hydrophilic nanosilica --- laboratory evaluation --- diatomite --- basalt fiber --- compound modify --- asphalt mixture --- asphalt mixture --- basalt fiber --- freeze-thaw cycle --- damage characteristics --- high-modulus asphalt mixture (HMAM) --- dynamic tests --- viscoelasticity --- dynamic responses --- resistance to deformations --- tensile strains --- tensile stresses --- sensitivity analysis --- hot mix asphalt containing recycled concrete aggregate --- contact angle --- adhesion energy --- water stability --- fatigue performance --- self-compacting concrete (SCC) --- rheology --- workability --- pozzolanic reaction --- microstructure --- Ultra-High Performance Concrete (UHPC) --- long-term drying shrinkage --- hydration characteristic --- porous pumice --- optimization --- engineered cementitious composites (ECC) --- polyvinyl alcohol --- fiber modification --- mechanical behavior --- self-healing --- asphalt --- rejuvenation --- calcium alginate capsules --- asphalt-aggregate adhesion --- plant ash lixivium --- stripping test --- contact angle --- interfacial transition zone --- SBS-modified bitumen --- rejuvenating systems --- physical properties --- viscous-elastic temperature --- rutting factor --- vibration noise consumption --- cold recycled asphalt mixture --- reclaimed asphalt pavement --- mastic --- rheological properties --- emulsified asphalt --- cement --- construction materials --- fatigue life --- ageing resistance --- modified asphalt materials --- rejuvenator --- self-healing asphalt --- recycling --- cold recycled asphalt mixture --- ultra-high performance concrete

Environment-Friendly Construction Materials

Authors: --- --- ---
ISBN: 9783039210145 / 9783039210152 Year: Pages: 256 DOI: 10.3390/books978-3-03921-015-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-06-26 08:44:06
License:

Loading...
Export citation

Choose an application

Abstract

Construction materials are the most widely used materials for civil infrastructure in our daily lives. However, from an environmental point of view, they consume a huge amount of natural resources and generate the majority of greenhouse gasses. Therefore, many new and novel technologies for designing environmentally friendly construction materials have been developed recently. This Special Issue, “Environment-Friendly Construction Materials”, has been proposed and organized as a means to present recent developments in the field of construction materials. It covers a wide range of selected topics on construction materials.

Keywords

Ca-alginate microcapsules --- microfluidic --- self-healing --- bitumen --- mineral-asphalt mixtures --- aggregate from sanitary ceramic wastes --- environmentally friendly construction materials --- diatomite --- styrene–butadiene–styrene (SBS) modified bitumen --- diatomite-modified asphalt mixture --- road engineering --- fatigue life --- three-point bending fatigue test --- asphalt mixture --- plateau value of permanent deformation ratio --- damage evolution --- fatigue equation --- ultraviolet radiation --- bitumen --- aging depth --- transmittance --- permeation --- expanded graphite --- polyethylene glycol --- phase change materials --- titanate coupling agent --- molecular bridge --- building envelopes --- thermal property --- building energy conservation --- reclaimed asphalt pavement --- recycling --- epoxidized soybean oil --- rejuvenator --- diffusing --- asphalt pavement --- fatigue property --- pavement failure --- long-term field service --- asphalt mixture --- microwave heating --- induction heating --- effective heating depth --- induced healing --- initial self-healing temperature --- asphalt mastic --- flow behavior index --- steel slag --- limestone --- aggregate morphology --- aggregate image measurement system --- micro-surfacing --- skid-resistance --- surface texture --- asphalt --- water solute exposure --- aqueous solute compositions --- chemical evolutions --- rheological properties --- polyacrylic acid --- fluidity --- rheology --- adsorption --- combination --- cement emulsified asphalt mixture --- fatigue performance --- thickness combinations --- X-ray computed tomography --- artificial neural network --- crumb rubber --- high-strength concrete --- damping --- dynamic moduli --- railway application --- recycled material --- recycling --- sanitary ceramics --- concrete --- recycling aggregate --- asphalt mixture --- basalt fiber --- response surface methodology --- design optimization --- fluorescence spectrum --- bitumen --- ageing --- parametrization --- “blue-shift” --- asphalt --- asphalt mortar --- healing agents --- crack healing --- healing model --- ultra-thin wearing course --- self-healing --- induction heating --- steel fiber --- steel slag --- rankinite --- carbonation --- waste concrete --- CO2 --- aged bitumen --- rejuvenator --- solubilizer --- colloidal structure --- micro-morphology --- granite aggregate --- desulphurization gypsum residues --- rubber modified asphalt --- asphalt mixture --- pavement performance --- limestone aggregates --- emulsified asphalt --- demulsification speed --- surface energy --- specific surface area --- artificially aged asphalt mixture --- rejuvenator --- durability --- dynamic characteristics --- overlay tester --- energy-based approach --- dissipated strain energy --- plateau value of dissipated strain energy ratio --- fatigue life --- three-point bending fatigue test --- amorphous silica --- crystallization sensitivity --- water-leaching pretreatment --- rice husk ash --- cement --- crumb rubber --- anti-rutting agent --- flexibility --- field evaluation --- asphalt mixes --- aggregate characteristics --- simplex lattice design --- viscoelastic properties --- asphalt combustion --- flame retardant --- aluminum hydroxide --- layered double hydroxide --- asphalt mixture --- viscoelastic properties --- creep --- relaxation --- aggregates --- morphology --- crumb rubber powder --- SBS/CRP-modified bitumen --- aging processes --- temperature sensitivity characteristics --- diatomite --- basalt fiber --- asphalt mixture --- low-temperature --- damage constitutive model --- graphene --- nitrogen and phosphorus removal --- MDA --- SOD --- sequencing batch Chlorella reactor --- SEM --- thermal–mechanical properties --- bio-oil --- regeneration --- aged asphalt --- molecular dynamic simulation --- viscoelasticity --- nanomaterial --- hydrophobic nanosilica --- hydrophilic nanosilica --- laboratory evaluation --- diatomite --- basalt fiber --- compound modify --- asphalt mixture --- asphalt mixture --- basalt fiber --- freeze-thaw cycle --- damage characteristics --- high-modulus asphalt mixture (HMAM) --- dynamic tests --- viscoelasticity --- dynamic responses --- resistance to deformations --- tensile strains --- tensile stresses --- sensitivity analysis --- hot mix asphalt containing recycled concrete aggregate --- contact angle --- adhesion energy --- water stability --- fatigue performance --- self-compacting concrete (SCC) --- rheology --- workability --- pozzolanic reaction --- microstructure --- Ultra-High Performance Concrete (UHPC) --- long-term drying shrinkage --- hydration characteristic --- porous pumice --- optimization --- engineered cementitious composites (ECC) --- polyvinyl alcohol --- fiber modification --- mechanical behavior --- self-healing --- asphalt --- rejuvenation --- calcium alginate capsules --- asphalt-aggregate adhesion --- plant ash lixivium --- stripping test --- contact angle --- interfacial transition zone --- SBS-modified bitumen --- rejuvenating systems --- physical properties --- viscous-elastic temperature --- rutting factor --- vibration noise consumption --- cold recycled asphalt mixture --- reclaimed asphalt pavement --- mastic --- rheological properties --- emulsified asphalt --- cement --- construction materials --- fatigue life --- ageing resistance --- modified asphalt materials --- rejuvenator --- self-healing asphalt --- recycling --- cold recycled asphalt mixture --- ultra-high performance concrete

Environment-Friendly Construction Materials

Authors: --- --- ---
ISBN: 9783039210169 / 9783039210176 Year: Pages: 270 DOI: 10.3390/books978-3-03921-017-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-06-26 08:44:06
License:

Loading...
Export citation

Choose an application

Abstract

Construction materials are the most widely used materials for civil infrastructure in our daily lives. However, from an environmental point of view, they consume a huge amount of natural resources and generate the majority of greenhouse gasses. Therefore, many new and novel technologies for designing environmentally friendly construction materials have been developed recently. This Special Issue, “Environment-Friendly Construction Materials”, has been proposed and organized as a means to present recent developments in the field of construction materials. It covers a wide range of selected topics on construction materials.

Keywords

Ca-alginate microcapsules --- microfluidic --- self-healing --- bitumen --- mineral-asphalt mixtures --- aggregate from sanitary ceramic wastes --- environmentally friendly construction materials --- diatomite --- styrene–butadiene–styrene (SBS) modified bitumen --- diatomite-modified asphalt mixture --- road engineering --- fatigue life --- three-point bending fatigue test --- asphalt mixture --- plateau value of permanent deformation ratio --- damage evolution --- fatigue equation --- ultraviolet radiation --- bitumen --- aging depth --- transmittance --- permeation --- expanded graphite --- polyethylene glycol --- phase change materials --- titanate coupling agent --- molecular bridge --- building envelopes --- thermal property --- building energy conservation --- reclaimed asphalt pavement --- recycling --- epoxidized soybean oil --- rejuvenator --- diffusing --- asphalt pavement --- fatigue property --- pavement failure --- long-term field service --- asphalt mixture --- microwave heating --- induction heating --- effective heating depth --- induced healing --- initial self-healing temperature --- asphalt mastic --- flow behavior index --- steel slag --- limestone --- aggregate morphology --- aggregate image measurement system --- micro-surfacing --- skid-resistance --- surface texture --- asphalt --- water solute exposure --- aqueous solute compositions --- chemical evolutions --- rheological properties --- polyacrylic acid --- fluidity --- rheology --- adsorption --- combination --- cement emulsified asphalt mixture --- fatigue performance --- thickness combinations --- X-ray computed tomography --- artificial neural network --- crumb rubber --- high-strength concrete --- damping --- dynamic moduli --- railway application --- recycled material --- recycling --- sanitary ceramics --- concrete --- recycling aggregate --- asphalt mixture --- basalt fiber --- response surface methodology --- design optimization --- fluorescence spectrum --- bitumen --- ageing --- parametrization --- “blue-shift” --- asphalt --- asphalt mortar --- healing agents --- crack healing --- healing model --- ultra-thin wearing course --- self-healing --- induction heating --- steel fiber --- steel slag --- rankinite --- carbonation --- waste concrete --- CO2 --- aged bitumen --- rejuvenator --- solubilizer --- colloidal structure --- micro-morphology --- granite aggregate --- desulphurization gypsum residues --- rubber modified asphalt --- asphalt mixture --- pavement performance --- limestone aggregates --- emulsified asphalt --- demulsification speed --- surface energy --- specific surface area --- artificially aged asphalt mixture --- rejuvenator --- durability --- dynamic characteristics --- overlay tester --- energy-based approach --- dissipated strain energy --- plateau value of dissipated strain energy ratio --- fatigue life --- three-point bending fatigue test --- amorphous silica --- crystallization sensitivity --- water-leaching pretreatment --- rice husk ash --- cement --- crumb rubber --- anti-rutting agent --- flexibility --- field evaluation --- asphalt mixes --- aggregate characteristics --- simplex lattice design --- viscoelastic properties --- asphalt combustion --- flame retardant --- aluminum hydroxide --- layered double hydroxide --- asphalt mixture --- viscoelastic properties --- creep --- relaxation --- aggregates --- morphology --- crumb rubber powder --- SBS/CRP-modified bitumen --- aging processes --- temperature sensitivity characteristics --- diatomite --- basalt fiber --- asphalt mixture --- low-temperature --- damage constitutive model --- graphene --- nitrogen and phosphorus removal --- MDA --- SOD --- sequencing batch Chlorella reactor --- SEM --- thermal–mechanical properties --- bio-oil --- regeneration --- aged asphalt --- molecular dynamic simulation --- viscoelasticity --- nanomaterial --- hydrophobic nanosilica --- hydrophilic nanosilica --- laboratory evaluation --- diatomite --- basalt fiber --- compound modify --- asphalt mixture --- asphalt mixture --- basalt fiber --- freeze-thaw cycle --- damage characteristics --- high-modulus asphalt mixture (HMAM) --- dynamic tests --- viscoelasticity --- dynamic responses --- resistance to deformations --- tensile strains --- tensile stresses --- sensitivity analysis --- hot mix asphalt containing recycled concrete aggregate --- contact angle --- adhesion energy --- water stability --- fatigue performance --- self-compacting concrete (SCC) --- rheology --- workability --- pozzolanic reaction --- microstructure --- Ultra-High Performance Concrete (UHPC) --- long-term drying shrinkage --- hydration characteristic --- porous pumice --- optimization --- engineered cementitious composites (ECC) --- polyvinyl alcohol --- fiber modification --- mechanical behavior --- self-healing --- asphalt --- rejuvenation --- calcium alginate capsules --- asphalt-aggregate adhesion --- plant ash lixivium --- stripping test --- contact angle --- interfacial transition zone --- SBS-modified bitumen --- rejuvenating systems --- physical properties --- viscous-elastic temperature --- rutting factor --- vibration noise consumption --- cold recycled asphalt mixture --- reclaimed asphalt pavement --- mastic --- rheological properties --- emulsified asphalt --- cement --- construction materials --- fatigue life --- ageing resistance --- modified asphalt materials --- rejuvenator --- self-healing asphalt --- recycling --- cold recycled asphalt mixture --- ultra-high performance concrete

Listing 1 - 5 of 5
Sort by
Narrow your search