Search results: Found 17

Listing 1 - 10 of 17 << page
of 2
>>
Sort by
Karolinska Institutet 200-Year Anniversary Symposium on Injuries to the Spinal Cord and Peripheral Nervous System - An Update on Recent Advances in Regenerative Neuroscience

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453245 Year: Pages: 74 DOI: 10.3389/978-2-88945-324-5 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2018-02-27 16:16:45
License:

Loading...
Export citation

Choose an application

Abstract

The present E-book consists of original articles and reviews published in our Research Topic on injuries to the spinal cord and peripheral nerves and presents a wide array of novel findings and in depth discussions on topics within the field of nerve injury and repair. Our aim with this Research Topic is to bring together knowledge spanning from basic laboratory studies to clinical findings and strategies within the field of spinal cord and nerve injury and repair. We hope this publication will provide a basis for accelerated knowledge exchange within the field and hopefully a subsequent increase in research efforts and collaborations.

Root Systems Biology

Author:
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192755 Year: Pages: 130 DOI: 10.3389/978-2-88919-275-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Botany --- General and Civil Engineering --- Biotechnology
Added to DOAB on : 2015-12-03 13:02:24
License:

Loading...
Export citation

Choose an application

Abstract

The understanding of biological complexity has been greatly facilitated by cross-disciplinary, holistic approaches that allow insights into the function and regulation of biological processes that cannot be captured by dissecting them into their individual components. In addition, the development of novel tools has dramatically increased our ability to interrogate information at the nucleic acid, protein and metabolite level. The integration and interpretation of disparate data sets, however, still remain a major challenge in systems biology. Roots provide an excellent model for studying physiological, developmental, and metabolic processes. The availability of genetic resources, along with sequenced genomes has allowed important discoveries in root biochemistry, development and function. Roots are transparent, allowing optical investigation of gene activity in individual cells and experimental manipulation. In addition, the predictable fate of cells emerging from the root meristem and the continuous development of roots throughout the life of the plant, which permits simultaneous observation of different developmental stages, provide ideal premises for the analysis of growth and differentiation. Moreover, a genetically fixed cellular organization allows for studying the utilization of positional information and other non-cell-autonomous phenomena, which are of utmost importance in plant development. Although their ontogeny is largely invariant under standardized experimental conditions, roots possess an extraordinary capacity to respond to a plethora of environmental signals, resulting in distinct phenotypic readouts. This high phenotypic plasticity allows research into acclimative and adaptive strategies, the understanding of which is crucial for germplasm enhancement and crop improvement. With the aim of providing a current snapshot on the function and development of roots at the systems level, this Research Topic collated original research articles, methods articles, reviews, mini reviews and perspective, opinion and hypotheses articles that communicate breakthroughs in root biology, as well as recent advances in research technologies and data analysis.

Ecophysiology of root systems-environment interaction

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192854 Year: Pages: 316 DOI: 10.3389/978-2-88919-285-4 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2015-12-10 11:59:07
License:

Loading...
Export citation

Choose an application

Abstract

There is a scarcity of detailed information regarding the ecophysiology of root systems and the way root system functioning is affected by both internal and external factors. Furthermore, global climate change is expected to increase the intensity of climate extremes, such as severe drought, heat waves and periods of heavy rainfall; in addition other stresses such as salinization of soils are increasing world-wide. Recently an increasing awareness has developed that understanding plant traits will play a major role in breeding of future crop plants. For example, there is increasing evidence that the traits of root systems are defined by the properties of individual roots. However, further knowledge on the functional importance of root segments and the molecular/physiological mechanisms underlying root system functioning and persistence is needed, and would specifically allow modifying (crop) root system functionality and efficiency in the future. Another major gap in knowledge is localized at the root-soil interface and in regard to the potential adaptive plasticity of root-rhizosphere interactions under abiotic stress and/or competition. It is currently unknown whether adaptations in microbe communities occur, for example due to modified exudation rates, and what are the subsequent influences on nutrient mobilization and uptake. Furthermore, uncovering the mechanisms by which roots perceive neighboring roots may not only contribute to our understanding of plant developmental strategies, but also has important implications on the study of competitive interactions in natural communities, and in optimizing plant performance and resource use in agricultural and silvicultural systems. In this Research Topic, we aimed to provide an on-line, open-access snapshot of the current state of the art of the field of root ecology and physiology, with special focus on the translation of root structure to function, and how root systems are influenced by interplay with internal and external factors such as abiotic stress, microbes and plant-plant interaction. We welcomed original research papers, but reviews of specific topics, articles formulating opinions or describing cutting-edge methods were also gladly accepted.

Plant Single Cell Type Systems Biology

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199488 Year: Pages: 149 DOI: 10.3389/978-2-88919-948-8 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Botany
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

The phenotype of a plant in response to a stress condition is the reflection of the molecular responses in different cell-types composing the plant. The multicellular complexity represents a challenge when accessing specific responses of each cell or cell type composing the plant. To overcome this difficulty and allow the clear characterization of the plant cell molecular mechanisms, the research community is now focusing on studying a single cell and single cell-types. The isolation of plant single cells is limited by the cell wall that confers the rigidity of the plant and its overall structure. Various methods have been developed for isolating plant cells (e.g. laser capture microdissection; cell sorting of Green Fluorescent Protein (GFP)-tagged protoplasts, differential protoplastization of cells such as guard cells, isolation of easily accessible cell types such as cotton fiber, pollen cells, trichomes and root hair cells). The development of these innovative approaches to isolate single plant cells or cell-types combined with the application of sensitive and high-throughput technologies allows a better analysis of the developmental processes and response to environmental stresses. Ultimately, single plant cell and cell-type biology will lead to establishment of more reliable and accurate -molecular regulatory networks at the resolution of basic life unit. The goal of this Research Topic is to cover new technological and biological advances in the study of plant single cell, cell-type and systems biology.

Grassland-Invertebrate Interactions: Plant Productivity; Resilience and Community Dynamics

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452903 Year: Pages: 254 DOI: 10.3389/978-2-88945-290-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Botany --- Ecology
Added to DOAB on : 2018-02-27 16:16:44
License:

Loading...
Export citation

Choose an application

Abstract

Natural and anthropogenic grasslands such as prairies, meadows, rangelands, and pastures cover more than 40% of the planet’s surface and provide a wealth of ecological services. Grasslands alone store one third of the global carbon stocks and grass roots, through their specific architectures, ensure water cycling and prevent the erosion of fertile topsoil. In addition, grasslands are of vital importance for human food production as vast areas of rangelands and pastures provide feed for livestock. Pastoral legumes mobilize atmospheric nitrogen and improve fertility of arable soils. Not least, grasslands are an essential genetic resource. The three major crop species that feed half of the global population have been bred from wild grasses. Ancestors of our contemporary turf cultivars, common components of urban landscapes and recreation spaces, originated from wild grasslands. Although natural and managed grasslands represent pivotal ecosystems, many aspects of how they function are poorly understood. To date, most attention has focused on grassland primary producers (i.e. forage plants) and mammalian grazers but invertebrates are likely to play an equally, if not more important role in grassland ecosystem functioning. In Australian pastures, for example, the biomass of root-feeding scarab beetles can often exceed that of sheep and plant damage caused by invertebrates is sometimes equivalent to an average dairy cow’s grass consumption. Indeed, grasslands are one of the most densely populated ecosystems with invertebrates being probably the most important engineers that shape both plant communities and the grassland as a whole. In a rapidly changing world with increasing anthropogenic pressure on grasslands, this Research Topic focuses on: 1. How grassland habitats shape invertebrate biodiversity2. Impacts of climate change on grassland-invertebrate interactions3. Plant and invertebrate pest monitoring and management4. Plant-mediated multitrophic interactions and biological control in grasslands5. Land use and grassland invertebrates6. Plant resistance to invertebrate pests Given the increasing demand for food and land for human habitation, unprecedented threats to grasslands are anticipated. Resilient to some extent, these key ecosystems need to be better comprehended to guarantee their sustainable management and ecosystem services.

The Pathogenetic Mechanisms at the Basis of Aortopathy Associated with Bicuspid Aortic Valve: Insights from "Omics", Models of Disease and Emergent Technologies

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453955 Year: Pages: 170 DOI: 10.3389/978-2-88945-395-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2018-11-16 17:17:57
License:

Loading...
Export citation

Choose an application

Abstract

This forum of comprehensive reviews and research studies on distinct aspects of the pathophysiology of BAV aortopathy provides both the state of the art in the knowledge on this complex disease and novel insights into its causes and consequences. The present collection of focused papers also envisions and proposes new therapeutic strategies, novel biomarkers and original risk stratification criteria, for the improvement of patient management.

Performance Problem Diagnostics by Systematic Experimentation

Author:
Book Series: The Karlsruhe Series on Software Design and Quality / Ed. by Prof. Dr. Ralf Reussner ISSN: 18670067 ISBN: 9783731506775 Year: Volume: 20 Pages: XXVII, 443 p. DOI: 10.5445/KSP/1000070006 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-28 18:37:01
License:

Loading...
Export citation

Choose an application

Abstract

In this book, we introduce an automatic, experiment-based approach for performance problem diagnostics in enterprise software systems. The proposed approach systematically searches for root causes of detected performance problems by executing series of systematic performance tests. The presented approach is evaluated by various case studies showing that the presented approach is applicable to a wide range of contexts.

Regulation of Cell Fate Determination in Plants

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193240 Year: Pages: 84 DOI: 10.3389/978-2-88919-324-0 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
License:

Loading...
Export citation

Choose an application

Abstract

Plants are made up of a large number of distinct cell types that originate from a single fertilized egg cell. How the diversity of cell types arise in appropriate places is one of the most fascinating and attractive research areas of plant biology. During the past several decades, due to the development of new molecular techniques and tools, advances in optical microscopy, and availability of whole genome information and mutants in the model plant Arabidopsis and other plants, great advances have been made in understanding the mechanisms involved in cell fate determination in plants. Multiple mechanisms are used to generate cellular diversity. Asymmetric cell division is one of the primary mechanisms. As an example, asymmetric cell division enables one stem cell to generate a stem cell daughter and a daughter with a distinct identity. Initially equivalent cells can also differentiate to generate different cell types. This mechanism has been clearly demonstrated in the formation of multiple cell types during epidermis development in the shoot and root. Cell fate determination is influenced by both intrinsic factors, i.e, developmental regulators, as well as extrinsic signals, i.e., environmental stimuli. By using model systems like stomata, trichome, root hair and shoot and root apical meristem cells, ligands, receptors and transcription factors have been found to regulate cell fate determination. However, the details of signaling cassettes responsible for cell fate determination remain largely unknown. Plants are made up of a large number of distinct cell types that originate from a single fertilized egg cell. How the diversity of cell types arise in appropriate places is one of the most fascinating and attractive research areas of plant biology. During the past several decades, due to the development of new molecular techniques and tools, advances in optical microscopy, and availability of whole genome information and mutants in the model plant Arabidopsis and other plants, great advances have been made in understanding the mechanisms involved in cell fate determination in plants. This research topic contains 12 collected articles, including 2 Opinion Articles, 5 Reviews, 4 Mini Reviews, and 1 Original Research Article. Hopefully, these articles will expand our understanding of the regulation of cell fate determination in plants.

Roots - The Hidden Provider

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452446 Year: Pages: 243 DOI: 10.3389/978-2-88945-244-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Botany
Added to DOAB on : 2018-02-27 16:16:44
License:

Loading...
Export citation

Choose an application

Abstract

Nonparametric Econometric Methods and Application

Author:
ISBN: 9783038979647 / 9783038979654 Year: Pages: 224 DOI: 10.3390/books978-3-03897-965-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-06-26 08:44:06
License:

Loading...
Export citation

Choose an application

Abstract

The present Special Issue collects a number of new contributions both at the theoretical level and in terms of applications in the areas of nonparametric and semiparametric econometric methods. In particular, this collection of papers that cover areas such as developments in local smoothing techniques, splines, series estimators, and wavelets will add to the existing rich literature on these subjects and enhance our ability to use data to test economic hypotheses in a variety of fields, such as financial economics, microeconomics, macroeconomics, labor economics, and economic growth, to name a few.

Listing 1 - 10 of 17 << page
of 2
>>
Sort by
Narrow your search