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Pleiotropic Action of Selenium in the Prevention and Treatment of Cancer, and Related Diseases

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ISBN: 9783038976929 Year: Pages: 166 DOI: 10.3390/books978-3-03897-693-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2019-04-05 11:07:22
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This book will cover topics related to the preparation and use of heterogeneous catalytic systems for the transformation of renewable sources, as well as of materials deriving from agro-industrial wastes and by-products. At the same time, the ever-increasing importance of bioproducts, due to the acceptance and request of consumers, makes the upgrade of biomass into chemicals and materials not only an environmental issue, but also an economical advantage.

Selenium Isotope Studies in Plants - Development and Validation of a Novel Geochemical Tool and its Application to Organic Samples

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Book Series: Karlsruher mineralogische und geochemische Hefte : Schriftenreihe des Instituts für Angewandte Geowissenschaften ISSN: 16182677 ISBN: 9783731505945 Year: Volume: 42 Pages: XXV, 223 p. DOI: 10.5445/KSP/1000060292 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Ethnology
Added to DOAB on : 2019-07-30 20:02:00
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Selenium (Se), being an essential nutrient and a toxin, enters the food chain mainly via plants. Selenium isotope signatures were proved to be an excellent redox tracer, making it a promising tool for the exploration of the Se cycle in plants. The analytical method is sensitive on organic samples and requires particular preparation methods, which were developed and validated in this study. Plant cultivation setups revealed the applicability of these methods to trace plant internal processes.

Dietary Trace Minerals

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ISBN: 9783039283248 9783039283255 Year: Pages: 208 DOI: 10.3390/books978-3-03928-325-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-04-07 23:07:08
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Dietary trace minerals are pivotal and hold a key role in numerous metabolic processes. Trace mineral deficiencies (except for iodine, iron, and zinc) do not often develop spontaneously in adults on ordinary diets; infants are more vulnerable because their growth is rapid and their intake varies. Trace mineral imbalances can result from hereditary disorders (e.g., hemochromatosis, Wilson disease), kidney dialysis, parenteral nutrition, restrictive diets prescribed for people with inborn errors of metabolism, or various popular diet plans. The Special Issue “Dietary Trace Minerals” comprised 13 peer-reviewed papers on the most recent evidence regarding the dietary intake of trace minerals, as well as their effect on the prevention and treatment of non-communicable diseases. Original contributions and literature reviews further demonstrated the crucial and central part that dietary trace minerals play in human health and development. This editorial provides a brief and concise overview of the content of the Dietary Trace Minerals Special Issue.

Micronutrients Intake and Status during Pregnancy and Lactation

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ISBN: 9783038978404 9783038978411 Year: Pages: 152 DOI: 10.3390/books978-3-03897-841-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-05-09 17:16:14
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Optimal nutrition is important during pregnancy and lactation for the health of both the mother and infant. Chronic deficiencies of both macronutrients and micronutrients are well established in developing countries. Although in developed countries overconsumption of macronutrients is a major issue, micronutrient deficiencies which occur concomitantly are no less of a concern. Furthermore in developed countries there is also the risk of excessive micronutrient intake from dietary supplements. Micronutrients have a role in fetal and neonatal health and also health in later life. Micronutrient deficiency or toxicity during pregnancy or early life can permanently affect developing tissues, resulting in adverse growth and development of the infant which is associated with chronic diseases in adulthood. An aberrant micronutrient intake during pregnancy or lactation can also have detrimental effect on the mother both in the neonatal period and in later life.

Molecular Mechanisms and Genetics of Plant Resistance to Abiotic Stress

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ISBN: 9783039281220 9783039281237 Year: Pages: 152 DOI: 10.3390/books978-3-03928-123-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Plant Sciences
Added to DOAB on : 2020-04-07 23:07:08
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We are currently experiencing a climate crisis that is associated with extreme weather events worldwide. Some of its most noticeable effects are increases in temperatures, droughts, and desertification. These effects are already making whole regions unsuitable for agriculture. Therefore, we urgently need global measures to mitigate the effects of climate breakdown as well as crop alternatives that are more stress-resilient. These crop alternatives can come from breeding new varieties of well-established crops, such as wheat and barley. They can also come from promoting underutilized crop species that are naturally tolerant to some stresses, such as quinoa. Either way, we need to gather more knowledge on how plants respond to stresses related to climate breakdown, such as heat, water-deficit, flooding high salinity, nitrogen, and heavy metal stress. This Special Issue provides a timely collection of recent advances in the understanding of plant responses to these stresses. This information will definitely be useful to the design of new strategies to prevent the loss of more cultivable land and to reclaim the land that has already been declared unsuitable.

Carotenoids

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ISBN: 9783039218646 9783039218653 Year: Pages: 168 DOI: 10.3390/books978-3-03921-865-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-01-07 09:08:26
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Carotenoids are a group of natural pigments, consisting of more than 750 compounds. They are mostly yellow, orange, or red in color, due to the system of conjugated double bonds. This structural element is also responsible for the good antioxidant properties of many carotenoids. Carotenoids have shown numerous biological activities (not only as provitamin A), e.g., preventive properties of fruits and vegetables. As lipophilic compounds, their uptake and storage in the body are dependent on various conditions. In vitro and in vivo data showed stimulating and inhibitory effects of matrix compounds on bioaccessibility and bioavailability of carotenoids.

Keywords

?-carotene --- lycopene --- antioxidants --- free radicals --- ageing --- fruit --- vegetables --- ?-carotene --- HIV --- nelfinavir --- interaction --- pharmacokinetics --- carotenoids --- astaxanthin --- oxidative stress --- antioxidant --- chelating compound --- metal ions --- antireductant --- antiradical --- cationic lipid --- carotenoid --- antisense oligonucleotide --- exon skipping --- Duchenne muscular dystrophy --- ?-carotene --- lutein --- chlorophyll --- spent coffee grounds --- soil amendment --- lettuce --- accelerated solvent extraction --- pressurized fluid extraction --- ethanol --- carrots --- ?-carotene --- antioxidants --- marine carotenoids --- inflammation --- oxidative stress --- cardiovascular disease --- flavonoids --- carotenoids --- antioxidant synergism --- antioxidant antagonism --- free radical kinetics --- dye-sensitized solar cells --- carotenoid and chlorophyll derivatives --- singlet-triplet annihilation --- carotenoids --- xanthophylls --- fluorocarotenoids --- chlorocarotenoids --- bromocarotenoids --- iodocarotenoids --- silicon carotenoids --- nitrogen carotenoids --- sulfur carotenoids --- selenium carotenoids --- iron carotenoids --- carotenoids --- xanthophylls --- cancer chemoprevention --- mechanisms --- B16F10 --- ?-carotene --- PC-3 --- SK-Hep-1 --- VEGF --- oxidative stress --- ROS --- RNS --- antioxidants --- carotenoids --- cardiovascular disease --- carotenoids --- hydrophilic --- esterification --- PEG conjugates --- cycloaddition --- carotenoid --- stability --- feed processing --- storage --- carotenoids --- extraction --- solubility --- injection solvent --- liquid chromatography

Chemical Speciation of Organic and Inorganic components of Environmental and Biological Interest in Natural Fluids: Behaviour, Interaction and Sequestration

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ISBN: 9783039284528 9783039284535 Year: Pages: 218 DOI: 10.3390/books978-3-03928-453-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Sociology --- Social Sciences
Added to DOAB on : 2020-04-07 23:07:09
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The International Union of Pure and Applied Chemistry (IUPAC) defines the term “speciation” as the distribution of an element amongst defined chemical species in a system, while the process leading to quantitative estimation of the content of different species is called speciation analysis. The chemical speciation of elements in natural waters and biological fluids is a key topic, essential for discussing the chemical reactivity of constituents in these systems. It is well understood that it is the chemical form of a metal or metalloids that determines its reactivity, lifetime, and fate in the environment. Chemical speciation now involves various sectors of the sciences, from chemistry to biology, biochemistry, and environmental sciences, since—as is well known—the total concentration, alone, of an inorganic or organic component (metal or ligand) in a multicomponent natural system (fresh water, sea water, biological fluids, soil, etc.) is insufficient for a comprehensive understand of its behavior in those contests.

New Mineral Species and Their Crystal Structures

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ISBN: 9783038976882 Year: Pages: 204 DOI: 10.3390/books978-3-03897-689-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-04-05 11:07:22
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One last comment concerns the fundamental contributions of Fourier analysis to quantum physics: Quantum mechanics and quantum field theory.

Keywords

ariegilatite --- nabimusaite group --- new mineral --- crystal structure --- intercalated hexagonal antiperovskite --- CO3-group --- Raman --- pyrometamorphic rocks --- Hatrurim Complex --- tiberiobardiite --- chalcophyllite group --- copper --- silicate --- sulfate --- Cretaio --- Tuscany --- Italy --- oyonite --- lillianite homologous series --- sulfosalt --- copper --- antimony --- arsenic --- Oyon district --- Lima department --- Peru --- fiemmeite --- new oxalate mineral --- Val di Fiemme --- Trentino --- Italy --- sharyginite --- new mineral --- crystal structure --- Raman spectroscopy --- Bellerberg volcano --- Germany --- kurchatovite --- clinokurchatovite --- crystal structure --- borate --- polymorphism --- polytypism --- structural complexity --- structural combinatorics --- configurational entropy --- least-action principle --- barioferrite --- crystal structure --- single-crystal investigation --- Raman --- Hatrurim Complex --- Rusinovite --- Raman spectroscopy --- pyrometamorphism --- stacking faults --- Shadil-Khokh volcano --- Bellerberg volcano --- aurihydrargyrumite --- Au6Hg5 phase --- gold --- placer --- self-electrorefining --- Ehime --- Japan --- cerromojonite --- selenium --- copper --- lead --- mercury --- bismuth --- sou?ekite --- bournonite group --- El Dragón --- Bolivia --- nöggerathite-(Ce) --- new mineral --- zirconolite --- laachite --- sanidinite --- crystal structure --- alkaline volcanic rock --- Laacher See --- Eifel --- parafiniukite --- apatite supergroup --- hedyphane group --- manganese --- calcium --- phosphorus --- Szklary pegmatite --- Lower Silesia --- Poland --- thermaerogenite --- cuprospinel --- gahnite --- magnesioferrite --- CuAl2O4 --- CuFe2O4 --- copper oxide --- new mineral --- spinel supergroup --- fumarole sublimate --- Tolbachik volcano --- Kamchatka --- verneite --- new mineral --- crystal structure --- Hekla --- Vesuvius --- Eldfell --- aluminofluoride

Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation

Authors: ---
ISBN: 9783039212651 9783039212668 Year: Pages: 356 DOI: 10.3390/books978-3-03921-266-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-08-28 11:21:27
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Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses.

Keywords

major depressive disorder --- glioblastoma --- differentially expressed genes --- transcriptomics --- common pathway --- mouse --- miR-25-3p --- Akt1 --- AP-2? --- promoter --- cell metabolism --- p57Kip2 --- CDKN1C --- epigenetics --- disease --- cell differentiation --- placenta --- long non-coding RNA (lncRNA) --- human --- pregnancy --- high-throughput RNA sequencing (RNA-Seq) --- transcriptome --- Rsh regulon --- Novosphingobium pentaromativorans US6-1 --- sphingomonads --- RNA-seq --- N-acyl-l-homoserine lactone --- ppGpp --- selenium --- selenocysteine --- selenoproteins --- selenocysteine insertion sequence --- nonsense-mediated decay --- G-quadruplex --- transcriptional regulation --- promoter --- CRISPR/Cas9 --- PRDM gene family --- TCGA data analysis --- somatic mutations --- transcriptome profiling --- human malignancies --- tristetraprolin (TTP) --- tumorigenesis --- posttranscriptional regulation --- adenosine and uridine-rich elements (AREs) --- circRNA-disease associations --- pathway --- heterogeneous network --- Patau Syndrome --- cytogenetics --- FOXO1 --- transcription factor --- molecular pathways --- bioinformatics --- molecular docking --- and drug design --- transcription regulation --- gene expression --- causal inference --- enhancer activity --- insect --- transcription factors --- structures and functions --- research methods --- progress and prospects --- Pax3 --- Pteria penguin (Röding, 1798) --- tyrosinase --- melanin --- RNA interference --- liquid chromatograph-tandem mass spectrometer (LC-MS/MS) --- epigenetics --- gene expression --- nutrition --- transcription --- disorders --- mechanisms --- Crassostrea gigas --- Pacific oyster --- pediveliger larvae --- bioadhesive --- transcriptome --- gene expression --- interactome --- microscopy --- fertilization --- self-incompatibility --- transcriptome --- tea --- long non-coding RNAs --- cancer --- acute leukemia --- therapeutic targets --- Adiponectin --- cancer --- Adiponectin receptors --- obesity --- inflammatory response --- inflammation --- nutritional status --- n/a

Human Milk and Lactation

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ISBN: 9783039289233 / 9783039289240 Year: Pages: 368 DOI: 10.3390/books978-3-03928-924-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-06-09 16:38:57
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Human milk is uniquely tailored to meet infants’ specific nutritional requirements. However, it is more than just “milk”. This dynamic and bioactive fluid allows mother–infant signalling over lactation, guiding the infant in the developmental and physiological processes. It exerts protection and life-long biological effects, playing a crucial role in promoting healthy growth and optimal cognitive development. The latest scientific advances have provided insight into different components of human milk and their dynamic changes over time. However, the complexity of human milk composition and the synergistic mechanisms responsible for its beneficial health effects have not yet been unravelled. Filling this knowledge gap will shed light on the biology of the developing infant and will contribute to the optimization of infant feeding, particularly that of the most vulnerable infants. Greater understanding of human milk will also help in elucidating the best strategies for its storage and handling. The increasing knowledge on human milk’s bioactive compounds together with the rapidly-advancing technological achievements will greatly enhance their use as prophylactic or therapeutic agents. The current Special Issue aims to welcome original works and literature reviews further exploring the complexity of human milk composition, the mechanisms underlying the beneficial effects associated with breastfeeding, and the factors and determinants involved in lactation, including its promotion and support.

Keywords

human milk --- preterm --- term --- infants --- lipids --- fatty acids --- human milk fortification --- docosahexaenoic acid (DHA) --- mothers’ own milk --- donor human milk --- arachidonic acid (ARA) --- eicosapentaenoic acid (EPA) --- bioactive factors --- carotenoids --- dietary intake --- high-performance liquid chromatography (HPLC) --- human milk --- lactation --- maternal diet --- prospective study --- Human Milk --- Preterm infant --- Phospholipids --- Lipidomics --- Milk Fat Globule Membrane --- breastfeeding --- late preterm --- protective factors --- promotion of breastfeeding --- breastfeeding support --- mammary gland --- immune-active proteins --- proteases --- protease inhibitors --- digestive tract --- antenatal --- expressing --- pregnancy --- video instruction --- colostrum --- breastfeeding --- online --- clinical trial --- lactation --- infants --- breastfeeding --- lactating women --- human milk benefits --- colostrum --- milk therapy --- bioactive factors --- 2?-fucosyllactose (2?FL) --- 3?-sialyllactose (3?SL) --- disialyllacto-N-tetraose (DSLNT) --- human milk oligosaccharides (HMO) --- milk group --- secretor --- Lewis --- lactation --- preterm --- adipokines --- antioxidants --- breastfeeding --- cytokines --- growth factors --- human milk --- preterm --- term --- neonate --- infant --- macronutrients --- protein --- fat --- lactose --- nutrition --- passive immunization --- maternal immunoglobulins --- lactation --- prematurity --- flu vaccine --- human milk --- human milk --- omega-3 fatty acids --- docosahexaenoic acid --- eicosapentaenoic acid --- ?-linolenic acid --- dietary intake --- food frequency questionnaire --- vitamin D deficiency --- supplementation --- breastfeeding --- mothers --- infants --- human milk --- targeted metabolomics --- amino acids --- lipid metabolites --- LC-MS --- flow injection analysis --- human milk --- protein --- glycoprotein --- endogenous peptide --- breastfeeding --- hormones --- adipokines --- breast milk --- growth --- body composition --- term infant --- human milk --- term --- preterm --- calcium --- phosphorus --- magnesium --- zinc --- iron --- copper --- iodine --- selenium --- potassium --- sodium --- n-9 fatty acid --- nervonic acid --- human milk fat --- infant formula --- lactational stage --- donor human milk --- high pressure processing --- carotenoids --- antioxidant capacity --- lipids --- bile salt stimulated lipase --- preterm --- retinol --- ?-tocopherol --- inadequate intake --- nutritional status --- breast milk --- undernourishment --- dietary assessment --- multiple source method --- human milk --- celiac disease --- hormones --- fatty acids --- duration of lactation --- country --- carbohydrate --- fat --- breastfeeding difficulties --- early breastfeeding cessation --- term infants --- breastfeeding support --- human milk --- donor milk --- choline --- phosphocholine --- storage --- pasteurization --- milk banking --- pumping --- breastfeeding --- lactation --- n/a

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