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Modeling and Analysis of Signal Transduction Networks

ISBN: 9783038421412 9783038421429 Year: Pages: 232 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-12 12:19:39
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Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential drug targets. Elucidating the dynamic behavior of the components of pathways, and their interactions, is one of the key research areas of systems biology. Biological signaling networks are characterized by a large number of components and an even larger number of parameters describing the network. Furthermore, investigations of signaling networks are characterized by large uncertainties of the network as well as limited availability of data due to expensive and time-consuming experiments. As such, techniques derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter estimation, are important tools for elucidating the mechanisms involved in signaling networks. This Special Issue contains papers that investigate a variety of different signaling networks via established, as well as newly developed modeling and analysis techniques.

Framework for Analysis and Identification of Nonlinear Distributed Parameter Systems using Bayesian Uncertainty Quantification based on Generalized Polynomial Chaos

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Book Series: Karlsruher Schriften zur Anthropomatik / Lehrstuhl für Interaktive Echtzeitsysteme, Karlsruher Institut für Technologie ; Fraunhofer-Inst. für Optronik, Systemtechnik und Bildauswertung IOSB Karlsruhe ISSN: 18636489 ISBN: 9783731506423 Year: Volume: 31 Pages: XIX, 210 p. DOI: 10.5445/KSP/1000066940 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:01:59
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In this work, the Uncertainty Quantification (UQ) approaches combined systematically to analyze and identify systems. The generalized Polynomial Chaos (gPC) expansion is applied to reduce the computational effort. The framework using gPC based on Bayesian UQ proposed in this work is capable of analyzing the system systematically and reducing the disagreement between the model predictions and the measurements of the real processes to fulfill user defined performance criteria.

Model-Based Tools for Pharmaceutical Manufacturing Processes

Authors: --- --- ---
ISBN: 9783039284245 9783039284252 Year: Pages: 188 DOI: 10.3390/books978-3-03928-425-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-04-07 23:07:09
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The Special Issue on “Model-Based Tools for Pharmaceutical Manufacturing Processes” will curate novel advances in the development and application of model-based tools to address ever-present challenges of the traditional pharmaceutical manufacturing practice as well as new trends. This book provides a collection of nine papers on original advances in the model-based process unit, system-level, quality-by-design under uncertainty, and decision-making applications of pharmaceutical manufacturing processes.

Smart Sustainable Manufacturing Systems

Authors: ---
ISBN: 9783039212019 9783039212026 Year: Pages: 158 DOI: 10.3390/books978-3-03921-202-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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With the advent of disruptive digital technologies, companies are facing unprecedented challenges and opportunities. Advanced manufacturing systems are of paramount importance in making key enabling technologies and new products more competitive, affordable, and accessible, as well as for fostering their economic and social impact. The manufacturing industry also serves as an innovator for sustainability since automation coupled with advanced manufacturing technologies have helped manufacturing practices transition into the circular economy. To that end, this Special Issue of the journal Applied Sciences, devoted to the broad field of Smart Sustainable Manufacturing Systems, explores recent research into the concepts, methods, tools, and applications for smart sustainable manufacturing, in order to advance and promote the development of modern and intelligent manufacturing systems. In light of the above, this Special Issue is a collection of the latest research on relevant topics and addresses the current challenging issues associated with the introduction of smart sustainable manufacturing systems. Various topics have been addressed in this Special Issue, which focuses on the design of sustainable production systems and factories; industrial big data analytics and cyberphysical systems; intelligent maintenance approaches and technologies for increased operating life of production systems; zero-defect manufacturing strategies, tools and methods towards online production management; and connected smart factories.

Agricultural Irrigation

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ISBN: 9783039219223 9783039219230 Year: Pages: 172 DOI: 10.3390/books978-3-03921-923-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Agriculture (General)
Added to DOAB on : 2019-12-09 11:49:16
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Agriculture is certainly the most important food supplier while it globally accounts for more than 70% of water used and contributes significantly to water pollution. Irrigated agriculture is facing rising competition worldwide for access to reliable, low cost, and high-quality water resources. However, irrigation as the major tool and determinant of affecting agricultural productivity and environmental resources plays a critical role in food security and environment sustainability. Innovative irrigation technologies and practices may enhance agricultural water efficiency and production, in the meantime decrease the water demand and quality issues. I am very pleased to invite you to submit manuscripts in agricultural irrigation which assess current challenges and offer improvement approaches and opportunities for future irrigation.

Hydrothermal Technology in Biomass Utilization & Conversion

Authors: --- ---
ISBN: 9783039286768 / 9783039286775 Year: Pages: 166 DOI: 10.3390/books978-3-03928-677-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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This book addresses a key innovative technology for decarbonization of the energy system: hydrothermal processing. It basically consists of treating biomass and wastes in a wet form, under pressure and temperature condition. This approach is becoming more and more attractive, as new feedstock and applications are appearing on the scene of bioeconomy and bioenergy. The hydrothermal processing of various type of biomass, waste, and residues, thus, raised the interest of many researchers and companies around the world, together with downstream upgrading processes and technologies: solid products as biochar, for instance, or liquid ones as crude bioliquids, are finding new market opportunities in circular economy schemes. The Special Issue collects recent innovative research works in the field, from basic to applied research, as well as pilot industrial applications/demo. It is a valuable set of references for those investing time and effort in research in the field.

Process Modelling and Simulation

Authors: --- ---
ISBN: 9783039214556 9783039214563 Year: Pages: 298 DOI: 10.3390/books978-3-03921-456-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Since process models are nowadays ubiquitous in many applications, the challenges and alternatives related to their development, validation, and efficient use have become more apparent. In addition, the massive amounts of both offline and online data available today open the door for new applications and solutions. However, transforming data into useful models and information in the context of the process industry or of bio-systems requires specific approaches and considerations such as new modelling methodologies incorporating the complex, stochastic, hybrid and distributed nature of many processes in particular. The same can be said about the tools and software environments used to describe, code, and solve such models for their further exploitation. Going well beyond mere simulation tools, these advanced tools offer a software suite built around the models, facilitating tasks such as experiment design, parameter estimation, model initialization, validation, analysis, size reduction, discretization, optimization, distributed computation, co-simulation, etc. This Special Issue collects novel developments in these topics in order to address the challenges brought by the use of models in their different facets, and to reflect state of the art developments in methods, tools and industrial applications.

Keywords

process model validation --- partial least square regression --- phytochemicals --- natural extracts --- wheat germ --- fluidized bed drying --- mathematical model --- moisture content --- condensation --- simulation --- Pharmaceutical Processes --- Mammalian Cell Culture --- sensitivity analysis --- parameter estimation --- Design of Experiments --- algebraic modeling language --- dynamic optimization --- model predictive control --- moving horizon estimation --- fluid bed granulation --- heat and mass balance --- population balance model --- binder dissolution --- kernel development --- robust optimization --- uncertainty --- point estimation method --- equality constraints --- parameter correlation --- barley --- simulation --- hydration --- swelling --- cooking --- porridge --- extents --- graph theory --- model identification --- observability --- optimal clustering --- parameter estimation --- state decoupling --- data-mining --- machine learning --- neural networks --- chemistry --- materials --- engineering --- energy --- grey-box model --- machine learning --- SOS programming --- process modeling --- scrap dissolution --- scrap melting --- thermodynamics --- kinetics --- dynamic converter modelling --- Combined Heat and Power --- gray-box model --- utility management --- CHP legislation --- optimization --- polyacrylonitrile-based carbon fiber --- coagulation bath --- dry-jet wet spinning process --- computational fluid dynamics --- wave resonance --- maximum wave amplitude --- reactor coolant pump --- vane --- costing stopping --- mathematical model --- idling test --- n/a

Improved Reservoir Models and Production Forecasting Techniques for Multi-Stage Fractured Hydrocarbon Wells

Authors: --- ---
ISBN: 9783039218929 9783039218936 Year: Pages: 238 DOI: 10.3390/books978-3-03921-893-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-01-07 09:08:26
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The massive increase in energy demand and the related rapid development of unconventional reservoirs has opened up exciting new energy supply opportunities along with new, seemingly intractable engineering and research challenges. The energy industry has primarily depended on a heuristic approach—rather than a systematic approach—to optimize and tackle the various challenges when developing new and improving the performance of existing unconventional reservoirs. Industry needs accurate estimations of well production performance and of the cumulative estimated ultimate reserves, accounting for uncertainty. This Special Issue presents 10 original and high-quality research articles related to the modeling of unconventional reservoirs, which showcase advanced methods for fractured reservoir simulation, and improved production forecasting techniques.

Advances in Mechanical Systems Dynamics

Authors: --- ---
ISBN: 9783039281886 9783039281893 Year: Pages: 236 DOI: 10.3390/books978-3-03928-189-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Mechanical Engineering --- General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-04-07 23:07:08
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Modern dynamics was established many centuries ago by Galileo and Newton before the beginning of the industrial era. Presently, we are in the presence of the fourth industrial revolution, and mechanical systems are increasingly being integrated with electronic, electrical, and fluidic systems. This trend is present not only in the industrial environment, which will soon be characterized by the cyber-physical systems of industry 4.0, but also in other environments like mobility, health and bio-engineering, food and natural resources, safety, and sustainable living. In this context, purely mechanical systems with quasi-static behavior will become less common and the state-of-the-art will soon be represented by integrated mechanical systems, which need accurate dynamic models to predict their behavior. Therefore, mechanical system dynamics are going to play an increasingly central role. Significant research efforts are needed to improve the identification of the mechanical properties of systems in order to develop models that take non-linearity into account, and to develop efficient simulation tools. This Special Issue aims at disseminating the latest research achievements, findings, and ideas in mechanical systems dynamics, with particular emphasis on applications that are strongly integrated with other systems and require a multi-physical approach.

Tools, Methodologies and Techniques Applied to Sustainable Supply Chains

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ISBN: 9783039283187 9783039283194 Year: Pages: 296 DOI: 10.3390/books978-3-03928-319-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Business and Management
Added to DOAB on : 2020-04-07 23:07:08
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Supply chains are currently globalized and companies operate internationally owing to the fact that raw materials, production processes, and the consumption of the final products are carried out in different countries. This implies high material and information flow, which incurs high costs associated with the supply chain and logistics, sometimes up to 60% of the total cost of the product. Therefore, companies seek to optimize their resources to reduce these costs and improve sustainability in a globalized market. This book, entitled Tools, Methodologies and Techniques Applied to Sustainable Supply Chains, contains 15 chapters that report case studies applied to industrial and service sectors. The authors come from areas such as Mexico, Colombia, Italy, Sweden, Slovakia, China, and Australia. They indicate how managers make use of tools and techniques to solve problems associated with supply chains to reduce their cost and remain competitive. A great effort has been made to analyze this problem, and the methodologies are clearly described here to facilitate the reproducibility of each technique and tool. This was done in the hope that hoping that they may one day be applied in more companies.

Keywords

tire waste management --- reverse logistics --- green logistics --- Mexico --- Russia --- remanufacturing --- closed-loop supply chain --- warranty decision --- contract coordination --- supply chain innovation --- systematic review --- social network analysis --- collaboration --- attributes --- green manufacturing --- benefits --- green supply chain --- sensitivity analysis --- sustainability --- genetic algorithm --- layout planning --- model --- sustainable manufacturing --- environmental assessment tool --- green lean --- pallet management strategy --- reusable handling system --- closed-loop network --- what-if analysis --- environmental impact --- electricity markets --- alpha-stable distribution --- alpha-stable regression --- electricity prices --- waste management --- residue collection --- urban logistics --- design of territories --- supply chain management --- hospital supply chain --- sustainable supply chain --- hospital logistics --- hospital sustainability --- healthcare logistics --- sustainable hospital management --- Sugarcane Crop Residues (SCRs) --- cogeneration --- optimization of bioenergy supply chain decisions --- delivering products --- travel time uncertainty --- fuzzy logic --- fuzzy linear programming --- urban road network --- reliability --- green supplier selection --- contract farming --- life cycle assessment --- environmental collaboration --- multi-objective optimization --- agro-food supply chain --- system dynamics --- systems thinking --- causal models --- healthcare services --- bearability --- sustainability --- MIPL --- VRP --- star network --- optimal plant location

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