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Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies (Book chapter)

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ISBN: 9789533077031 Year: DOI: 10.5772/23332 Language: English
Publisher: IntechOpen Grant: FP7 Ideas: European Research Council - 243188
Subject: Science (General)
Added to DOAB on : 2019-01-17 11:47:59
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Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species&#xD;&#xD;(ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes&#xD;&#xD;the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and&#xD;&#xD;human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells&#xD;&#xD;become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953).&#xD;&#xD;Because of this so-called “oxygen enhancement effect”, the radiation dose required to&#xD;&#xD;achieve the same biologic effect is about three times higher in the absence of oxygen than in&#xD;&#xD;the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009).&#xD;&#xD;Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well&#xD;&#xD;oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of&#xD;&#xD;fractionated radiotherapy (Rojas et al., 1992).

Basic Knowledge and Conditions on Knowledge

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ISBN: 9781783742851 9781783742837 Year: Volume: 1 Pages: 238 DOI: http://doi.org/10.11647/OBP.0104 Language: English
Publisher: Open Book Publishers
Subject: Philosophy
Added to DOAB on : 2017-11-01 17:24:17
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How do we know what we know? In this stimulating and rigorous book, Mark McBride explores two sets of issues in contemporary epistemology: the problems that warrant transmission poses for the category of basic knowledge; and the status of conclusive reasons, sensitivity, and safety as conditions that are necessary for knowledge.To have basic knowledge is to know (have justification for) some proposition immediately, i.e., knowledge (justification) that doesn’t depend on justification for any other proposition. This book considers several puzzles that arise when you take seriously the possibility that we can have basic knowledge.McBride’s analysis draws together two vital strands in contemporary epistemology that are usually treated in isolation from each other. Additionally, its innovative arguments include a new application of the safety condition to the law.This book will be of interest to epistemologists―both professionals and students.

High-resolution sensitivity studies with the regional climate model COSMO-CLM

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Book Series: Wissenschaftliche Berichte des Instituts für Meteorologie und Klimaforschung der Universität Karlsruhe (TH) ISSN: 01795619 ISBN: 9783866442283 Year: Volume: 42 Pages: 191 p. DOI: 10.5445/KSP/1000007813 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Astronomy (General)
Added to DOAB on : 2019-07-30 20:02:01
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High-resolution regional ensemble climate simulations with the regional climate model COSMO-CLM are performed for Southwest Germany to study the sensitivity of meteorological and hydrological variables to parameter settings. The soil-vegetation model VEG3D is implemented into COSMO-CLM to assess the impact of the lower atmospheric boundary on simulation results. A statistical-dynamical downscaling method is tested to shorten the simulation time for regional climate studies.

Modeling and Analysis of Signal Transduction Networks

ISBN: 9783038421412 9783038421429 Year: Pages: 232 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-12 12:19:39
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Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential drug targets. Elucidating the dynamic behavior of the components of pathways, and their interactions, is one of the key research areas of systems biology. Biological signaling networks are characterized by a large number of components and an even larger number of parameters describing the network. Furthermore, investigations of signaling networks are characterized by large uncertainties of the network as well as limited availability of data due to expensive and time-consuming experiments. As such, techniques derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter estimation, are important tools for elucidating the mechanisms involved in signaling networks. This Special Issue contains papers that investigate a variety of different signaling networks via established, as well as newly developed modeling and analysis techniques.

Gluten Related Disorders: People Shall not Live on Bread Alone

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ISBN: 9783038423577 9783038423560 Year: Pages: X, 242 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine
Added to DOAB on : 2017-05-05 13:32:03
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Once upon a time, gluten was not part of the human diet, and therefore, there were no gluten-related disorders. With the advent of agriculture 10,000 years ago, the introduction of gluten-containing grains in the human diet created conditions for human diseases related to gluten exposure. These diseases, including celiac disease, non-celiac gluten sensitivity, and wheat allergy, have distinct pathophysiological mechanisms, serological markers, and long-term treatments, but similar, often overlapping clinical presentations. Though current research strives to clarify the boundaries between these entities, their differences can be difficult to distinguish.For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders has been a “work in progress”. New epidemiological studies have revealed that gluten-related disorders are not limited to European regions; rather, they are present worldwide.After centuries of neglected attention to celiac disease and other forms of gluten reaction, now we are observing another interesting phenomenon that is generating great confusion among health care professionals. Nearly 25% of Americans (many more than the projected 3 million celiac disease (CD) patients in the U.S.) are reducing or cutting gluten from their diets. This remarkable trend in the general population reflects the misconception that gluten can be harmful for everybody and, therefore, should be avoided to stay healthy, to lose weight, or even to prevent severe diseases.This Special Issue Book of Nutrients contains contributions from leading experts in the field of gluten-related disorders that will help dissipate this confusion by sharing their evidence-based science, which will help the reader to distinguish facts from fantasies.

Electrical-field sensitive YBa?Cu?O??? detectors for real-time monitoring of picosecond THz pulses

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Book Series: Karlsruher Schriftenreihe zur Supraleitung / Hrsg. Prof. Dr.-Ing. M. Noe, Prof. Dr. rer. nat. M. Siegel ISSN: 18691765 ISBN: 9783731507864 Year: Volume: 21 Pages: XIV, 199 p. DOI: 10.5445/KSP/1000081476 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:01
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This work investigates the capability of the high-temperature superconductor YBCO to sense the evolution of the electrical field of THz pulses. A deposition process for ten unit-cell thin films and a sub-µm patterning process were developed to enable high sensitivities. The detector response to THz exctiations and its electrical-field sensitivity were studied. This unique characteristic allows for the investigation of instabilities of the THz radiation emitted from synchrotron storage rings.

Nutrition and Celiac Disease

ISBN: 9783906980638 9783906980645 Year: Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 11:28:32
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During its 2.5 million years of evolution, the human species has evolved through major dramatic changes, mainly dictated by natural elements and, most importantly, by food availability. The diet of hunters and gatherers, hominids, was mainly based on fruit, vegetables, tubers, and occasionally meat and fish. Then, approximately 10,000 years ago, a drastic change in life style occurred, shifting from nomadic to settlers with domestication of animals and crops. A consequence of this change was the advent of wheat and other grains containing gluten-related proteins in human diet. This revolutionary transformation occurred at the Fertile Crescent, the modern-day Iraq, and spread from South to North and East to West at a speed of approximately 1 km/year. Ever since, the distribution of food goods became more and more uneven with wealthy countries getting more than necessary, while poor countries struggle with malnutrition and consequently this increased mortality. Unfortunately, the industrial revolution, rather than closing the gap, created even more inequalities that still exist today, leading to very different but equally worrisome pathologies, namely obesity in industrialized countries and famine in developing countries. [...]

Individual Differences: From Neurobiological Bases to New Insight on Approach and Avoidance Behavior

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197156 Year: Pages: 110 DOI: 10.3389/978-2-88919-715-6 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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The superordinate division of emotions is distributed along a bipolar dimension of affective valence, from approaching rewarding situations to avoiding punitive situations. Avoiding and approaching behaviors determine the disposition to the primary emotions of fear and attachment and the behavioral responses to the environmental stimuli of danger, novelty and reward. Approach or avoidance behaviors are associated with the brain pathways controlling cognitive and attentional function, reward sensitivity and emotional expression, involving prefrontal cortex, amygdala, striatum and cerebellum. Individual differences in approach and avoidance behavior might be modulated by normal variance in the level of functioning of different neurotransmitter systems, such as dopaminergic, serotoninergic, noradrenergic and endocannabinoid systems as well as many peptides such as corticotropin releasing hormone. These substances act at various central target areas to increase intensity of appetitive or defensive motivation. Physiologically, personality temperaments of approach and avoidance are viewed as instigators of propensity. They produce immediate affective, cognitive and behavioral inclinations in response to stimuli and orient individuals across domains and situations in a consistent fashion. Although the action undoubtedly emerges directly from these temperamental proclivities, ultimate behavioral outcomes are often a function of the integration among goal pursuit, self-regulation, and temperament trait. Defective coping strategies to aversive or rewarding stimuli characterize the patho-physiology of anxiety- and stress-related disorders or compulsive and addiction behaviors, respectively. Individuals with neuropsychiatric symptoms such as depression, suicidal behavior, bipolar mania, schizophrenia, substance use disorders, pathological gambling and anxiety disorders have scores which fall at the extreme tails of the normal distribution for a specific temperamental trait. The present Research Topic on the individual differences in emotional and motivational processing emphasizes the link between neuronal pattern and behavioral expression. The Topic includes experimental and clinical researches addressing the individual differences related to approach and avoidance and their behavioral characterization, structural and neurochemical profiles, synaptic connections, and receptor expressions. Studies are organized in a framework that puts in evidence the phenotypic expression and neurobiological patterns characterizing the individual differences and their biological variance.

Framework for Analysis and Identification of Nonlinear Distributed Parameter Systems using Bayesian Uncertainty Quantification based on Generalized Polynomial Chaos

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Book Series: Karlsruher Schriften zur Anthropomatik / Lehrstuhl für Interaktive Echtzeitsysteme, Karlsruher Institut für Technologie ; Fraunhofer-Inst. für Optronik, Systemtechnik und Bildauswertung IOSB Karlsruhe ISSN: 18636489 ISBN: 9783731506423 Year: Volume: 31 Pages: XIX, 210 p. DOI: 10.5445/KSP/1000066940 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:01:59
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In this work, the Uncertainty Quantification (UQ) approaches combined systematically to analyze and identify systems. The generalized Polynomial Chaos (gPC) expansion is applied to reduce the computational effort. The framework using gPC based on Bayesian UQ proposed in this work is capable of analyzing the system systematically and reducing the disagreement between the model predictions and the measurements of the real processes to fulfill user defined performance criteria.

Gluten-Free Diet

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ISBN: 9783038977360 9783038977377 Year: Pages: 318 DOI: 10.3390/books978-3-03897-737-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-04-25 16:37:17
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In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.

Keywords

Celiac Disease --- depression --- gluten-free diet --- dietary adherence --- gluten --- gastric emptying --- cholecyst --- celiac disease --- non celiac gluten sensitivity --- gluten-free diet --- gastrointestinal symptoms --- quality of life --- Brazilian CD-QoL --- quality of life --- celiac disease --- questionnaire --- coeliac disease --- celiac disease --- gluten --- gluten-free diet --- fortification --- micronutrient --- cost --- celiac disease --- diagnosis --- gliadin --- gluten --- glutenin --- non-celiac gluten sensitivity --- oral food challenge --- pepsin --- wheat allergy --- celiac disease (CD) --- quality of life (QoL) --- gluten-free diet --- disease duration --- place of residence --- educational level --- economic status --- body mass index (BMI) --- celiac disease --- gluten-free diet --- gut microbiota --- gluten-free diet --- celiac disease --- children --- teenagers --- gluten-related disorders --- celiac disease --- gut microbiota --- gluten-free diet --- Pseudomonas --- gluten-free diet --- mineral --- deficiency --- calcium --- iron --- magnesium --- zinc --- celiac disease --- non-celiac gluten sensitivity --- gut motility --- gluten-free diet --- gluten-related disorders --- gluten-free diet --- coeliac disease --- non-coeliac gluten sensitivity --- irritable bowel syndrome --- mood disorders --- affective disorders --- depression --- major depressive disorder --- mental health --- nutrition --- celiac disease --- gluten-free diet --- diary recommended intake --- food habit --- body composition --- non-coeliac gluten sensitivity --- gluten --- wheat --- low FODMAP diet --- irritable bowel syndrome --- beta cell --- beta-cell stress --- celiac disease --- gluten-free diet --- high-fat diet-induced obesity --- intestinal permeability --- islet of Langerhans --- NOD mouse --- type 1 diabetes --- type 2 diabetes --- FODMAP intake --- celiac disease --- irritable bowel syndrome --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- gluten-free diet --- effectiveness --- adherence --- nutritionists --- clinic --- serology --- duodenal biopsies --- structured questionnaires --- peptides derived from gluten in faeces and urine --- gluten --- adherence --- serology --- villous atrophy --- mucosal recovery --- threshold --- celiac disease --- body composition --- gluten free diet --- children --- celiac disease --- gluten --- gluten-free diet --- screening --- outcome --- gluten sensitivity --- osteoporosis --- non-celiac gluten sensitivity --- gluten re-introduction --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- ?-gliadin --- 33-mer --- DQ2.5-glia-?1 --- DQ2.5-glia-?2 --- DQ2.5-glia-?3 epitopes --- wheat species --- n/a --- gluten --- gluten-free diet --- coeliac disease --- non-celiac gluten sensitivity --- non-coeliac wheat sensitivity --- gliadin --- microbiota

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