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This Special Issue contains a series of excellent research works on telecommunications and signal processing, selected from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP) which was held on July 4–6, 2018, in Athens, Greece. The conference was organized in cooperation with the IEEE Region 8 (Europe, Middle East, and Africa), IEEE Greece Section, IEEE Czechoslovakia Section, and IEEE Czechoslovakia Section SP/CAS/COM Joint Chapter by seventeen universities from the Czech Republic, Hungary, Turkey, Taiwan, Japan, Slovak Republic, Spain, Bulgaria, France, Slovenia, Croatia, and Poland, for academics, researchers, and developers, and serves as a premier international forum for the annual exchange and promotion of the latest advances in telecommunication technology and signal processing. The aim of the conference is to bring together both novice and experienced scientists, developers, and specialists, to meet new colleagues, collect new ideas, and establish new cooperation between research groups from universities, research centers, and private sectors worldwide. This collection of 10 papers is highly recommended for researchers, and believed to be interesting, inspiring, and motivating for readers in their further research.

activation process --- EPON --- GPON --- MATLAB --- NG-PON2 --- timing --- transmission convergence layer --- XG-PON --- authentication --- identification --- security --- wireless communication --- machine learning --- phonation --- acoustic analysis --- follow-up study --- hypokinetic dysarthria --- Parkinson’s disease --- pattern recognition --- dynamic time warping --- maximum likelihood criterion --- similarity measure --- multitemporal data --- multispectral information --- cognitive radio --- interference alignment --- interference leakage --- multi-hop relay network --- Parkinson’s disease dysgraphia --- micrographia --- online handwriting --- kinematic analysis --- fractional-order derivative --- fractional calculus --- electrocardiogram (ECG) --- Least Absolute Shrinkage and Selection Operator (LASSO) --- overcomplete multi-scale dictionary construction --- signal representation --- sparse inference --- fractional-order filters --- fractional calculus --- Chebyshev filters --- low-pass filters --- magnitude responses --- time-interleaved analog-to-digital converter (TIADC) --- sample-and-hold (S/H) mismatch --- modulo M quasi-stationary --- Taylor series --- Richardson iteration --- 3D segmentation --- brain --- deep learning --- neural network --- open-source --- semantic segmentation --- spine --- u-net --- n/a