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Electric Power Systems Research

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ISBN: 9783038424048 9783038424055 Year: Pages: VIII, 364 DOI: 10.3390/books978-3-03842-404-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2017-06-09 09:42:57
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This book contains 21 research papers, one review and one editorial focusing on studies in the field of electric power systems research in 2016. These 23 published papers can be classified into five categories: generation systems; transmission systems; distribution systems; end-users; and the power market. Among these, the subjects of generation and distribution systems has caused the most concern due to the realization of smart grids. Papers presented in this book cover research, the development of new procedures or components, an original application of existing knowledge, or new design approaches. The authors of the published articles are from a variety of Asian, North American, and European countries. This book shows that authors in China are the most active and their research covers all of the above-mentioned areas.

Nonlinear Effects in Superconducting Quantum Interference Meta-Atoms

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Book Series: Experimental Condensed Matter Physics / Karlsruher Institut für Technologie, Physikalisches Institut ISSN: 21919925 ISBN: 9783731502944 Year: Volume: 15 Pages: II, 148 p. DOI: 10.5445/KSP/1000043835 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Physics (General)
Added to DOAB on : 2019-07-30 20:02:00
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This thesis deals with the nonlinear aspects of superconducting quantum interference devices (SQUIDs) as magnetic meta-atoms. Such meta-atoms are usually resonant structures that constitute the basic building blocks of a metamaterial with the purpose of giving the material unconventional magnetic properties. Due to their intrinsic nonlinearity, SQUIDs exhibit a number of phenomena such as frequency tunability and multi-stability that make them attractive as controllable meta-atoms.

Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454419 Year: Pages: 183 DOI: 10.3389/978-2-88945-441-9 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2018-11-16 17:17:57
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DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the deleterious consequences of DNA damage. It is estimated that every single cell receives tens of thousands of DNA lesions per day. Failure of DDR to properly respond to DNA damage leads to stem cell dysfunction, accelerated ageing, various degenerative diseases or cancer. The sole function of DDR is to recognize diverse DNA lesions, signal their presence, activate cell cycle arrest and finally recruit specific DNA repair proteins to fix the DNA damage and thus prevent genomic instability. DDR is composed of hundreds of spatiotemporally regulated and interconnected proteins, which are able to promptly respond to various DNA lesions. So it is not surprising that mutations in genes encoding various DDR proteins cause embryonic lethality, malignancies, neurodegenerative diseases and premature ageing. The importance of DDR for cell survival and genome stability is unquestionable, but how the sophisticated network of hundreds of different DDR proteins is spatiotemporally coordinated is far from being understood. In the last ten years ubiquitin (ubiquitination) and the ubiquitin-relative SUMO (sumoylation) have emerged as essential posttranslational modifications that regulate DDR. Beside a plethora of ubiqutin and sumo E1-activating enzymes, E2-conjugating enzymes, E3-ligases and ubiquitin/sumo proteases involved in ubiquitination and sumoylation, the complexity of ubiqutin and sumo systems is additionally increased by the fact that both ubiquitin and sumo can form a variety of different chains on substrates which govern the substrate fate, such as its interaction with other proteins, changing its enzymatic activity or promoting substrate degradation. The importance of ubiquitin/SUMO systems in the orchestration of DDR is best illustrated in patients with mutations in E3-ubiquitin ligases BRCA1 or RNF168. BRCA1 is essential for proper function of DDR and its mutations lead to triple-negative breast and ovarian cancers. RNF168 is an E3 ubiquitin ligase, which creates the ubiquitin docking platform for recruitment of different DNA damage signalling and repair proteins at sites of DNA lesion, and its mutations cause RIDDLE syndrome characterized by radiosensitivity, immunodeficiency and learning disability. In addition, recently discovered the ubiquitin receptor protein SPRTN is part of the DNA replication machinery and its mutations cause early-onset hepatocellular carcinoma and premature ageing in humans. Despite more than 700 different enzymes directly involved in ubiquitination and sumoylation processes only few of them are known to play a role in DDR. Therefore, we feel that the role of ubiquitin and the ubiquitin-related SUMO in DDR is far from being understood, and that this is the emerging field that will hugely expand in the next decade due to the rapid development of a new generation of technologies, which will allow us a more robust and precise analyses of human genome, transcriptome and proteome. In this Research Topic we provide a comprehensive overview of our current understanding of ubiquitin and SUMO pathways in all aspects of DDR, from DNA replication to different DNA repair pathways, and demonstrate how alterations in these pathways cause genomic instability that is linked to degenerative diseases, cancer and pathological ageing.

Microbial Community Modeling: Prediction of Microbial Interactions and Community Dynamics

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ISBN: 9783038429753 9783038429760 Year: Pages: VIII, 286 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemical Engineering
Added to DOAB on : 2018-07-04 13:24:50
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Investigating the microbiome is on the frontier of science. It has the potential to resolve many issues in the realms of energy, food, human health, the environment, and biotechnology. Scientists are trying to understand, in a fundamental way, how microbes influence each other and how they organize into interaction networks. These are the keys to predicting and engineering community function and properties of the microbiome. In this regard, mathematical modeling and computational analysis play an increasing role. This book is a collection of contributions from lead scientists in the field. It provides innovative approaches and fresh perspectives for modeling environmental communities and engineered microbial consortia. Reading this book will give researchers a solid look at cutting-edge science in microbial community modeling, and at the remaining challenges such modeling poses.

Flow control : theoretical concept of absolute instability

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ISBN: 9783866445314 Year: Pages: 97 p. DOI: 10.5445/KSP/1000016554 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
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At the 37th Prandtl memorial lecture on Regions of Viccous Flow, H.Oertel 1994 developed for the first time the stability theory of local perturbations in boundary layers and wake flows, as well as their practical application in the flow control of vehicle flows and the boundary layer of civil aircraft wings.This work presents how the stability theory concept of absolute instability has advanced and proven in practice in the last 15 years in terms of the efficient flow control.

Crosswind stability of vehicles under nonstationary wind excitation

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Book Series: Schriftenreihe des Instituts für Technische Mechanik, Karlsruher Institut für Technologie ISSN: 16143914 ISBN: 9783731503767 Year: Volume: 28 Pages: XXI, 178 p. DOI: 10.5445/KSP/1000047001 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
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This work has studied the crosswind stability of vehicles under nonstationary wind excitation in various scenarios. Railway vehicles running on curved and straight track with varying vehicle speed are studied. Road vehicles are classified into different categories. For each vehicle class, a corresponding worst-case vehicle model has been built. As the wind excitation on the vehicle is a stochastic process, a risk analysis has to be carried out and failure probabilities are computed and analyzed.

Tragverhalten von biegebeanspruchten Stahlmasten mit polygonalen Querschnitten

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Book Series: Berichte zum Stahl- und Leichtbau / Karlsruher Institut für Technologie, Versuchsanstalt für Stahl, Holz und Steine, Stahl- und Leichtbau ISSN: 21987912 ISBN: 9783731503989 Year: Volume: 2 Pages: getr. Zählung DOI: 10.5445/KSP/1000047608 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:59
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This work deals with the bending moment capacity of thin-walled steel poles with polygonal sections. Based on experimental and numerical investigations the bearing behavior of steel poles in bending with polygonal sections with an arbitrary number of corners up to the transition from a polygonal section to a round section is presented. Thereby the bearing behavior as a shell and the influence of imperfections are considered.

Stability of cooperation in the international climate negotiations - An analysis using cooperative game theory

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ISBN: 9783731507000 Year: Pages: XXII, 221 p. DOI: 10.5445/KSP/1000072088 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Business and Management
Added to DOAB on : 2019-07-30 20:02:02
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International cooperation on greenhouse gas emission reductions is needed to avoid dangerous climate change. This work analyses the stability of global cooperation on climate change using cooperative game theory. Numerical and theoretical models are applied to evaluate the impact of several real-world properties. It is shown that the introduction of these properties into the game-theoretical model substantially affects the results and can make global climate cooperation unstable.

iPS Cells for Modelling and Treatment of Human Diseases

ISBN: 9783038421221 9783038421214 Year: Pages: 422 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2016-05-09 15:30:07
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The field of reprogramming somatic cells into induced pluripotent stem cells (iPSC) has moved very quickly, from bench to bedside in just eight years since its first discovery. The best example of this is the RIKEN clinical trial this year in Japan, which will use iPSC derived retinal pigmented epithelial (RPE) cells to treat macular degeneration (MD). This is the first human disease to be tested for regeneration and repair by iPSC-derived cells and others will follow in the near future. Currently, there is an intense worldwide research effort to bring stem cell technology to the clinic for application to treat human diseases and pathologies. Human tissue diseases (including those of the lung, heart, brain, spinal cord, and muscles) drive organ bioengineering to the forefront of technology concerning cell replacement therapy. Given the critical mass of research and translational work being performed, iPSCs may very well be the cell type of choice for regenerative medicine in the future. Also, basic science questions, such as efficient differentiation protocols to the correct cell type for regenerating human tissues, the immune response of iPSC replacement therapy and genetic stability of iPSC-derived cells, are currently being investigated for future clinical applications.

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453894 Year: Pages: 123 DOI: 10.3389/978-2-88945-389-4 Language: English
Publisher: Frontiers Media SA
Subject: Biology --- Science (General) --- Chemistry (General)
Added to DOAB on : 2018-11-22 11:50:10
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The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS).To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.

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