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This book illustrates some of the most recent research efforts that have been made in lowering plasma cholesterol levels in patients with CVD. Selected articles aimed to illuminate advances and urgent challenges in the management of CVD, including disease management using statin-combined therapeutic strategies.

anacetrapib --- cholesteryl ester transfer protein --- cardiovascular disease --- apolipoprotein --- diabetes --- vaspin --- acute coronary syndrome --- NSTEMI --- STEMI --- lipoproteins --- atherosclerosis --- cardiovascular risk --- statin --- PCSK9 --- genetic --- nutrigenetics --- sterol --- cholesterol --- low-density lipoprotein cholesterol --- cardiovascular disease --- ABCA1 --- HDL --- miRNA --- circular RNA --- gene expression --- RNA-binding proteins --- reverse cholesterol transport --- cardiovascular diseases --- dyslipidemia --- type 2 diabetes --- PCSK9 --- nonstatin --- PCSK9 --- proprotein convertase subtilisin/kexin type 9 --- LDL subfractions --- sdLDL --- cardiovascular disease --- risk stratification --- proprotein convertase subtilisin-kexin type 9 (PCSK9) --- small interfering RNA (siRNA) --- inclisiran --- low-density lipoprotein-cholesterol (LDL-C) --- cardiovascular disease (CVD) --- cardiovascular risk --- atherosclerosis --- ceramides --- lipids --- lipoproteins --- miRNA --- sphingolipids --- sphingomyelin --- NAFLD --- NASH --- hepatic fibrosis --- hyperlipidemia --- statins --- statins --- coronary artery bypass grafting --- pleiotropic actions --- atrial fibrillation --- stroke --- acute kidney injury

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The impact of fat intake on hypercholesterolemia and related atherosclerotic cardiovascular diseases has been studied for decades. However, the current evidence base suggests that fatty acids also influences cardiometabolic diseases through other mechanisms including effects on glucose metabolism, body fat distribution, blood pressure, inflammation, and heart rate. Furthermore, studies evaluating single fatty acids have challenged the simplistic view of shared health effects within fatty acid groups categorized by degree of saturation. In addition, investigations of endogenous fatty acid metabolism, including genetic studies of fatty acid metabolizing enzymes, and the identification of novel metabolically derived fatty acids have further increased the complexity of fatty acids’ health impacts. This Special Issue aims to include original research and up-to-date reviews on genetic and dietary modulation of fatty acids, and the role and function of dietary and metabolically derived fatty acids in cardiometabolic health.

omega-3 --- cardiovascular disease --- statins --- type 2 diabetes mellitus --- medium-chain triglyceride --- long-chain triglyceride --- lipid metabolism --- klotho --- CKD --- fish oil --- fibrosis --- inflammation --- cardiometabolic disease --- unsaturated fat --- Mediterranean diet --- low-fat diet --- alternatively activated macrophages --- perivascular adipose tissue --- type 2 cytokines --- erucic acid --- fish --- seafood --- furan fatty acids --- docosapentaenoic acid --- conjugated fatty acids --- cardiovascular disease --- metabolic disease --- blood lipids --- inflammation --- antioxidant --- CYP450 eicosanoids --- omega-3 PUFA --- omega-6 PUFA --- blood pressure --- hemodynamics --- children --- EETs --- EEQs --- fatty acid --- diet --- genotype --- human --- FADS --- fatty acid --- desaturase --- Genome-wide association study (GWAS) --- Insulin sensitivity --- adipose tissue --- cholesterol ester --- omega 3 --- PUFA --- n-3 PUFA --- COPD --- inflammation --- coronary artery disease --- ischemic heart disease --- CAD --- CHD --- fat --- obesity --- body weight --- cohort study --- substitution models --- epidemiology --- prospective cohort study --- n-6 fatty acids --- n-3 fatty acids --- linoleic acid --- arachidonic acid