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Stem Cell Oncology

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ISBN: 9780815392729 9781351190152 Year: Pages: 354 Language: English
Publisher: Taylor & Francis
Subject: Science (General)
Added to DOAB on : 2019-01-17 11:45:30
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Stem cell research is one of the fascinating areas of contemporary biology, but, as with many expanding fields of scientific inquiry, research on stem cells raises scientific questions as&#xD;rapidly as it generates discoveries. Research on stem cell treatment continues to advance&#xD;knowledge about how an organism develops from a single cell and how healthy cells replace&#xD;damaged cells in adult organisms. The most important potential application of human stem&#xD;cells is the generation of cells and tissues that could be used for cell-based therapies, especially&#xD;oncology.&#xD;The Faculty of Medicine, Universitas Sumatera Utara, collaborated with the center of&#xD;excellence and innovation (Pusat Unggulan Inovasi /PUI). The Stem Cell center of the&#xD;Universitas Sumatera Utara (USU) organized an International Conference. The International&#xD;Stem Cell and Oncology Conference (ISCOC) 2017 was an comprehensive academic&#xD;conference in the field of stem cell and oncology research and also tropical medicine and&#xD;related scientific topics.&#xD;We expect this conference will benefit academics and practitioners in the field of health&#xD;sciences in Indonesia. During the two day conference, researchers presented the most recent&#xD;discoveries in stem cell and oncology and also general medical topics, and served as well in&#xD;establishing networking for joint researchers and collaboration among participants.&#xD;The editors and the scientific committee would like to thank the participants and express&#xD;their gratitude to Faculty of Medicine of the Universitas Sumatera Utara for their support&#xD;to ISCOC 2017. Lastly, we are most indebted for the generous support given by Universitas&#xD;Sumatera Utara, Medan, Sumatera Utara, Indonesia.

Keywords

oncology --- stem cell --- research --- biology --- conference

Advances in Hematopoietic Stem Cell Research

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ISBN: 9789533079301 Year: Pages: 478 DOI: 10.5772/1203 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:48

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This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

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ISBN: 9789535128656 9789535128663 Year: Pages: 258 DOI: 10.5772/62607 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:49

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Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.

Stromal Cells - Structure, Function, and Therapeutic Implications

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ISBN: 9781789849844 9781789849851 Year: Pages: 260 DOI: 10.5772/intechopen.71899 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

New Genetics, New Social Formations

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Book Series: Genetics and Society ISBN: 9780203962893 9780415393232 9780415759434 9781134162581 9781134162574 9781134162536 Year: DOI: 10.4324/9780203962893 Language: English
Publisher: Taylor & Francis
Subject: Medicine (General) --- Anthropology --- Sociology
Added to DOAB on : 2019-11-08 11:21:16
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New genetic technologies cut across a range of public regulatory domains and private lifeworlds, often appearing to generate an institutional void in response to the complex challenges they pose. As a result, a number of new social formations are being developed to legitimate public engagement and avoid the perceived democratic deficit that may result. Papers in this volume discuss a variety of these manifestations in a global context, including: genetic data banks committees of inquiry non-governmental organisations (NGOs) national research laboratories. These institutions, across both health and agriculture, are explored in such diverse locations as Amazonia, China, Finland, Israel, the UK and the USA. This volume exhibits a clear thematic coherence around the impact of the new genetics and their associated technologies on new social formations, and the case studies included have a significant international focus, showing a balance between theoretical and empirical approaches in this rapidly changing field. This innovative new volume will be of interest to postgraduates and professionals in the fields of sociology, social anthropology, science and technology studies, and environmental studies.

Stem Cell Genetic Fidelity

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194902 Year: Pages: 110 DOI: 10.3389/978-2-88919-490-2 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General) --- Oncology --- Medicine (General)
Added to DOAB on : 2015-11-16 15:44:59
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The vision of this Frontiers in Oncology Research Topic on "Stem Cell Genetic Fidelity" had the goal of steeping a diverse range of research perspectives to a first comprehensive synthesis of thought on the questions of how tissue stem cells manage gene mutation rate and the significance of that management in mammalian evolution and biology, in particular as it relates to tissue cell renewal, carcinogenesis, and aging. The primary focus was determinants of mutation rate in distributed stem cells (DSCs), which encompass all naturally occurring stem cells at all stages of mammalian development. In particular, contributions were sought that considered a broad range of aspects of the immortal DNA strand hypothesis for DSC genetic fidelity. Though proposed in 1975, only in the last decade has this landmark concept in tissue cell biology emerged as a central discussion in DSC research with increasing scrutiny and discussion by an increasing number of laboratories of diverse research perspectives and experimental approaches. With this hypothesis presenting a formidable technical challenge for experimental investigation, as would be expected, both supportive and unsupportive reports have been lining up. In the case of supportive studies, neither the range of applicable tissues nor the responsible molecular mechanisms are known; and the essential genomic process, non-random DNA template strand inheritance by asymmetrically self-renewing DSCs, has been suggested to potentially have other cellular roles besides reducing mutation rate. A major aspiration of this Research Topic was to create the first comprehensive, critical synthesis of current insights and viewpoints on the impact of the immortal DNA strand hypothesis in the history of DSC mutation research. A wide range of article types was considered including historical perspectives, critical reviews, critical commentaries, new hypotheses, new research perspectives, technical advances, and original research reports. Although treatments of the immortal DNA strand hypothesis were the major focus, the desired synthesis required integration of related ideas on mechanisms of DSC mutagenesis and its impact in the evolution of mammals, the emergence of cancers, and stem cell aging. As such, investigators focused on issues in e.g., germ stem cell mutagenesis, effects of environmental mutagens on DSC mutation rate, DSC mutation and tissue aging, determinations of types of mutations in DSCs, and the role of DSC mutation in cancer initiation were invited. Similarly, although the specific goal of the Research Topic was to enlighten DSC genetic fidelity in humans and other mammalians, informing contributions based on studies in other model organisms were also welcomed. To achieve even better representation of current experience, advances, and ideas in this field of investigation, these early contributors were encouraged to extend the opportunity to others who shared their interest in advancing our understanding of the mutability of DSCs and its significance in human biology.

Perspektiven des Medizinrechts im 21. Jahrhundert

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ISBN: 9783940344083 Year: Language: German
Publisher: Universitätsverlag Göttingen
Subject: Law
Added to DOAB on : 2011-11-04 00:00:00
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Series "Göttinger Schriften zum Medizinrecht" (medicine law), which deals with several important debates in modern medicine such as gene therapy, research with embryonic stem cells, bio databases, living organ donation, and in general the economisation of the health system.

Cell Fate

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198528 Year: Pages: 102 DOI: 10.3389/978-2-88919-852-8 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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The fundamental question of how an undifferentiated progenitor cell adopts a more specialized cell fate that then contributes to the development of specialized tissues, organs, organ systems and ultimately a unique individual of a given species has intrigued cell and developmental biologists for many years. Advances in molecular and cell biology have enabled investigators to identify genetic and epigenetic factors that contribute to these processes with increasing detail and also to define the various molecular characteristics of each cell fate with greater precision. Understanding these processes have also provided greater insights into disorders in which the normal mechanisms of cell fate determination are altered, such as in cancer and inherited malformations. With these advances have come techniques that facilitate the manipulation of cell fate, which have the potential to revolutionize the field of medicine by facilitating the repair and/or regeneration of diseased organs. Given the rapid advances that are occurring in the field, the articles in this eBook are both relevant and timely. These articles originally appeared online as part of the Research Topic “Cell Fate” overseen by my colleagues Dr. Lin, Dr. Buttitta, Dr. Maves, Dr. Dilworth, Dr. Paladini and myself and have been viewed extensively. Because of their popularity, they are now made available as an eBook, in a more easily downloadable form.Michael T. Chin

Transcriptional Regulation in Cancers and Metabolic Diseases

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197125 Year: Pages: 98 DOI: 10.3389/978-2-88919-712-5 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General) --- Internal medicine
Added to DOAB on : 2016-04-07 11:22:02
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The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression during the formation of malignant cells. Extensive work has been done on the critical TFs in various disease models. Despite the success of numerous TF-targeted therapies, there remain significant hurdles understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern TF action. This effort is now beginning to produce exciting new avenues of research. A clinically relevant topic for genetic change of TF is the mutant isoforms of p53, the most famous tumor suppressor. The p53 mutations either results in loss of function, or acting as dominant negative for wild-type protein, or ‘gain of function’ specifically promoting cancer survival. The gain of function is achieved by shifting p53 binding partner proteins, or changed genomic binding landscape leading to a cancer-promoting transcriptome. Another example of genetic change of TF causing malignancy is the AML-ETO fusion protein in the human t(8;21)-leukemia. The fusion protein is an active TF, and more interestingly, new studies link the disease causing role of AML-ETO to the unique transcriptome in the hematopoietic stem cells. Nuclear receptors (NR) are a group of ligand-dependent TFs governing the expression of genes involved in a broad range of reproductive, developmental and metabolic programs. Genetic changes and epigenetic modifications of NRs lead to cancers and metabolic diseases. Androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) are well studied NRs in prostate, breast and endometrial cancers. The development in sequencing technology and computational genomics enable us to investigate the transcription programs of these master TFs in an unprecedented level. This Research Topic aims to present the most up-to-date progress in the field of transcription regulation in cancers and metabolic diseases.

The European Blood and Marrow Transplantation Textbook for Nurses: Under the Auspices of EBMT

Authors: ---
ISBN: 9783319500256 9783319500263 Year: Pages: 311 DOI: https://doi.org/10.1007/978-3-319-50026-3 Language: English
Publisher: Springer Grant: European Society for Blood and Marrow Transplantation (EBMT)
Subject: Nursing
Added to DOAB on : 2018-07-27 15:13:48
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This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right.This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

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