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General Anesthesia: From Theory to Experiments

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197491 Year: Pages: 138 DOI: 10.3389/978-2-88919-749-1 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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General anesthesia is a standard medical procedure in today's hospital practice. Although in most cases the administration of anesthetics does not affect severely the patients health, side effects of anesthesia are well-known, such as nausea or cognitive impairment. Moreover 1-2 out of 1000 patients under surgery report a partial wake up from anesthesia during the operation. The reason for such a partial lack of control of depth of anesthesia is that medical procedures are highly optimized based on experience but the neural dynamics during general anesthesia is far from being understood. One reason for this lack of understanding is both the complex neural interactions of neurons on different spatial and temporal scales and the poorly understood action of anesthetics on neural populations. For instance, anesthetic agents act on synaptic receptors on a microscopic scale essentially evoking a macroscopic change of population activity, such as Local Field Potentials, EEG/MEG or resulting change of cerebral blood flow. This population effect then triggers the loss of consciousness in patients. This Research Topic aims to address recent theoretical and experimental advances in the field. The theoretical and experimental studies represent a good overview over the current state of research in the field and provides a deeper insight into the underlying neural mechanisms. Each article in the issue focusses on a specific current research topic in general anesthesia research and several articles introduce to the topic in a pedagogical way. The issue covers various types of anaesthesia and the most important topics in the field, such as (but not limited to) recent advances in theoretical models and states of consciousness reflected in experimental data, the connectivity changes observed during anesthesia or effects of specific drugs on brain activity. The introduction style of the papers facilitates the reader to understand the background of the research aspect and even allows readers not familiar with general anesthesia research to enter the research domain. Hence the Research Topic aims to provide on one hand an overview of the current state of the art and on the other hand a good starting point for new researchers in the field.

Good News - Bad News: The Two Faces of Immune Privilege

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193318 Year: Pages: 109 DOI: 10.3389/978-2-88919-331-8 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2016-03-10 08:14:32
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Immune privilege was once thought to be the property of a few select sites that include the eye, brain, testis, pregnant uterus and (of all things) the hamster cheek pouch, and was believed to be mainly based on sequestration behind blood-tissue barriers. This view has changed. Immune privilege is now considered to constitute a more general phenomenon through which tissues are able to actively direct and control immune responses taking place in their “territory” to preserve their structural and functional integrity in the face of inflammatory processes. These positive aspects of immune privilege can be hijacked by tumors to their survival advantage and to the detriment of the host. This Research Topic dissects the beneficial and deleterious consequences of immune privilege in terms of the cellular and molecular mechanisms that various tissues and tumors use, each in its own fashion, to regulate immune processes that affect them, at the local and the systemic level.

Invisible, but how? The depth of unconscious processing as inferred from different suppression techniques

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194209 Year: Pages: 143 DOI: 10.3389/978-2-88919-420-9 Language: English
Publisher: Frontiers Media SA
Subject: Psychology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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To what level are invisible stimuli processed by the brain in the absence of conscious awareness? It is widely accepted that simple visual properties of invisible stimuli are processed; however, the existence of higher-level unconscious processing (e.g., involving semantic or executive functions) remains a matter of debate. Several methodological factors may underlie the discrepancies found in the literature, such as different levels of conservativeness in the definition of “unconscious” or different dependent measures of unconscious processing. In this research topic, we are particularly interested in yet another factor: inherent differences in the amount of information let through by different suppression techniques. In the same conditions of well-controlled, conservatively established invisibility, can we show that some of the techniques in the “psychophysical magic” arsenal (e.g., masking, but also visual crowding, attentional blink, etc.) reliably lead to higher-level unconscious processing than others (e.g., interocular suppression)? Some authors have started investigating this question, using multiple techniques in similar settings . We argue that this approach should be extended and refined. Indeed, in order to delineate the frontiers of the unconscious mind using a contrastive method, one has to disentangle the limits attributable to unawareness itself, and those attributable to the technique inducing unawareness. The scope of this research topic is to provide a platform for scientists to contribute insights and further experiments addressing this fundamental question.

Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193806 Year: Pages: 97 DOI: 10.3389/978-2-88919-380-6 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General)
Added to DOAB on : 2015-12-03 13:02:24
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In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved multiple molecular immunotherapeutics, such as Ipilimumab; cellular immunotherapies (e.g. adoptive cell transfer) are being tested in phase II/III clinical trials. Immunotherapetics has evolved into a sophisticated field: Multimodal therapeutic regimens are administrated to induce focused responses, curtail side- effects and improve therapeutic efficacy. The lack of effective clinical assessment tools remains a major challenge. Because of the intricacy of antitumor response, it is essential to scrutinize individual tumor-targeting immune cells and their functions at the finest details - molecules. In this regard, flow cytometry analysis modernized hematology and allows characterization of surface molecular signature on individual cells. More recently, microchip technologies and new variations of cytometry have enormously expanded the spectrum, throughout and multiplexity of single cell analysis. Nowadays, tens of millions of readouts can be generated through the course of a cancer immunotherapy to monitor the abundance, phenotype and a myriad of effector functions of single immune cells. At the same time, big data analytics and data mining methodologies have been adapted to achieve sensible diagnostic interpretations. Such a marriage of technology and analytics opens the door for informative point-of-care assessment of therapeutic efficacy and ensures timely therapeutic decisions. The new generation of personalized clinical diagnostics will revolutionize healthcare in the years to come.

Visual Mismatch Negativity (vMMN) a Prediction Error Signal in the Visual Modality

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195602 Year: Pages: 202 DOI: 10.3389/978-2-88919-560-2 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Current theories of visual change detection emphasize the importance of conscious attention to detect unexpected changes in the visual environment. However, an increasing body of studies shows that the human brain is capable of detecting even small visual changes, especially if such changes violate non-conscious probabilistic expectations based on repeating experiences. In other words, our brain automatically represents statistical regularities of our visual environmental. Since the discovery of the auditory mismatch negativity (MMN) event-related potential (ERP) component, the majority of research in the field has focused on auditory deviance detection. Such automatic change detection mechanisms operate in the visual modality too, as indicated by the visual mismatch negativity (vMMN) brain potential to rare changes. VMMN is typically elicited by stimuli with infrequent (deviant) features embedded in a stream of frequent (standard) stimuli, outside the focus of attention. In this research topic we aim to present vMMN as a prediction error signal. Predictive coding theories account for phenomena such as mismatch negativity and repetition suppression, and place them in a broader context of a general theory of cortical responses. A wide range of vMMN studies has been presented in this Research Topic. Twelve articles address roughly four general sub-themes including attention, language, face processing, and psychiatric disorders. Additionally, four articles focused on particular subjects such as the oblique effect, object formation, and development and time-frequency analysis of vMMN. Furthermore, a review paper presented vMMN in a hierarchical predictive coding framework. Each paper in this Research Topic is a valuable contribution to the field of automatic visual change detection and deepens our understanding of the short term plasticity underlying predictive processes of visual perceptual learning.

Energy Dissipation and Vibration Control: Modeling, Algorithm and Devices

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ISBN: 9783038427858 9783038427865 Year: Pages: VIII, 254 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Industrial Engineering --- Technology (General)
Added to DOAB on : 2018-04-27 12:44:08
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While the study of vibration and energy dissipation is one of the oldest topics in engineering, it also encompasses some of the most exciting engineering problems of our time. From the exploration of deep sub-sea reservoirs to the stabilization of spacecraft in orbit, the problem of vibration control is ever present. To a certain extent, the technological progress of our civilization is tied to our understanding of vibration, and advances made in this field will only allow us to reach greater horizons. This book attempts to capture a glimpse of our current progress in this field by showcasing over 15 chapters of cutting-edge research performed by world leading experts in vibration control and energy dissipation. We hope the reader will be able to gain an understanding of the state-of-the-art, and if possible, be inspired by the vast scope and possibilities offered by the field of vibration control and energy dissipation.

UAV‐Based Remote Sensing Volume 1

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ISBN: 9783038427773 9783038427780 Year: Volume: 1 Pages: VIII, 388 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2018-04-27 15:10:10
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Active technological development has fuelled rapid growth in the number of Unmanned Aerial Vehicle (UAV) platforms being deployed around the globe. Novel UAV platforms, UAV-based sensors, robotic sensing and imaging techniques, the development of processing workflows, as well as the capacity of ultra-high temporal and spatial resolution data, provide both opportunities and challenges that will allow engineers and scientists to address novel and important scientific questions in UAV and sensor design, remote sensing and environmental monitoring.This work features papers on UAV sensor design, improvements in UAV sensor technology, obstacle detection, methods for measuring optical flow, target tracking, gimbal influence on the stability of UAV images, augmented reality tools, segmentation in digital surface models for 3D reconstruction, detection, location and grasping objects, multi-target localization, vision-based tracking in cooperative multi-UAV systems, noise suppression techniques , rectification for oblique images, two-UAV communication system, fuzzy-based hybrid control algorithms, pedestrian detection and tracking as well as a range of atmospheric, geological, , agricultural, ecological, reef, wildlife, building and construction, coastal area coverage, search and rescue (SAR), water plume temperature measurements, aeromagnetic and archaeological surveys applications

UAV‐Based Remote Sensing Volume 2

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ISBN: 9783038428558 9783038428565 Year: Volume: 2 Pages: VIII, 396 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2018-04-27 15:39:27
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ctive technological development has fuelled rapid growth in the number of Unmanned Aerial Vehicle (UAV) platforms being deployed around the globe. Novel UAV platforms, UAV-based sensors, robotic sensing and imaging techniques, the development of processing workflows, as well as the capacity of ultra-high temporal and spatial resolution data, provide both opportunities and challenges that will allow engineers and scientists to address novel and important scientific questions in UAV and sensor design, remote sensing and environmental monitoring.This work features papers on UAV sensor design, improvements in UAV sensor technology, obstacle detection, methods for measuring optical flow, target tracking, gimbal influence on the stability of UAV images, augmented reality tools, segmentation in digital surface models for 3D reconstruction, detection, location and grasping objects, multi-target localization, vision-based tracking in cooperative multi-UAV systems, noise suppression techniques , rectification for oblique images, two-UAV communication system, fuzzy-based hybrid control algorithms, pedestrian detection and tracking as well as a range of atmospheric, geological, , agricultural, ecological, reef, wildlife, building and construction, coastal area coverage, search and rescue (SAR), water plume temperature measurements, aeromagnetic and archaeological surveys applications

UAV or Drones for Remote Sensing Applications

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ISBN: 9783038970910 9783038970927 Year: Pages: 382 DOI: 10.3390/books978-3-03897-092-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Engineering
Added to DOAB on : 2018-11-23 11:46:40
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The rapid development and growth of unmanned aerial vehicles (UAVs) as a remote sensing platform, as well as advances in the miniaturization of instrumentation and data systems, have resulted in an increasing uptake of this technology in the environmental and remote sensing science communities.Although tough regulations across the globe may still limit the broader use of UAVs, their use in precision agriculture, ecology, atmospheric research, disaster response biosecurity, ecological and reef monitoring, forestry, fire monitoring, quick response measurements for emergency disaster, Earth science research, volcanic gas sampling, monitoring of gas pipelines, mining plumes, humanitarian observations and biological/chemo-sensing tasks continues to increase.This book provides a forum for high-quality peer-reviewed papers that broaden the awareness and understanding of UAV developments, applications of UAVs for remote sensing, and associated developments in sensor technology, data processing and communications, and UAV system design and sensing capabilities.The book covers the following topics:• improvements in UAV sensor technology;• UAV sensor design;• descriptions of processing algorithms applied to UAV-based imagery datasets;• the use of optical, multi-spectral, hyperspectral, laser, and optical SAR technologies onboard UAVs;• Artificial intelligence and data mining-based strategies from UAV-acquired datasets;• UAV onboard data storage, transmission, and retrieval;• multiple platform UAV, AUV, and ground robot networks;• UAV sensor applications including: precision agriculture, construction, mining, pest detection, forestry, wildlife tracking, atmosphere, wildfire monitoring and prevention, reef monitoring, Earth science research pollution monitoring, micro-climates, land use precision agriculture, ecology, atmospheric research, quick response measurements for emergency disaster.

UAV or Drones for Remote Sensing Applications

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ISBN: 9783038971115 9783038971122 Year: Pages: 346 DOI: 10.3390/books978-3-03897-112-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Engineering
Added to DOAB on : 2018-11-23 11:49:36
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The rapid development and growth of unmanned aerial vehicles (UAVs) as a remote sensing platform, as well as advances in the miniaturization of instrumentation and data systems, have resulted in an increasing uptake of this technology in the environmental and remote sensing science communities.Although tough regulations across the globe may still limit the broader use of UAVs, their use in precision agriculture, ecology, atmospheric research, disaster response biosecurity, ecological and reef monitoring, forestry, fire monitoring, quick response measurements for emergency disaster, Earth science research, volcanic gas sampling, monitoring of gas pipelines, mining plumes, humanitarian observations and biological/chemo-sensing tasks continues to increase.This book provides a forum for high-quality peer-reviewed papers that broaden the awareness and understanding of UAV developments, applications of UAVs for remote sensing, and associated developments in sensor technology, data processing and communications, and UAV system design and sensing capabilities.The book covers the following topics:• improvements in UAV sensor technology;• UAV sensor design;• descriptions of processing algorithms applied to UAV-based imagery datasets;• the use of optical, multi-spectral, hyperspectral, laser, and optical SAR technologies onboard UAVs;• Artificial intelligence and data mining-based strategies from UAV-acquired datasets;• UAV onboard data storage, transmission, and retrieval;• multiple platform UAV, AUV, and ground robot networks;• UAV sensor applications including: precision agriculture, construction, mining, pest detection, forestry, wildlife tracking, atmosphere, wildfire monitoring and prevention, reef monitoring, Earth science research pollution monitoring, micro-climates, land use precision agriculture, ecology, atmospheric research, quick response measurements for emergency disaster.

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