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Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450244 Year: Pages: 129 DOI: 10.3389/978-2-88945-024-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics
Added to DOAB on : 2018-02-27 16:16:44
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The invasive character of a primary cancer is greatly dependent on numerous interactions between tumor cells and their extracellular surroundings. Matricellular receptors are defined as (cell-surface) receptors that bind extracellular matrix (ECM) structural proteins and soluble factors dynamically acting on ECM homeostasis. Matricellular receptors mediate numerous signalings from the extracellular environment to cell nucleus and drive main biological functions that are cell growth, survival and migration. Numerous data from the last decade evidence that matricellular receptors are biosensors that allow to a tumor cell answering to microenvironmental variations, and in this sense they are important contributors to tumor cell malignancy. Matricellular receptors represent thus valuable targets for the development of original anti-cancer strategies. Original reports, bibliographic reviews or hypotheses are welcome to improve the basic knowledge of matricellular receptor properties, their spatio-temporal regulation, the dynamic formation of complex receptors and the impact of such interactions on the invasive properties of tumor cells. Biological, biophysical and pharmacological, as well as in silico contributions will be appreciated.

Keywords

Anti-cancer target --- disco

Prozessintegration des Target Costings in der Fertigungsindustrie am Beispiel Sondermaschinenbau

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Book Series: Reihe Informationsmanagement im Engineering Karlsruhe / Hrsg.: Karlsruher Institut für Technologie, Institut für Informationsmanagement im Ingenieurwesen (IMI) ISSN: 18605990 ISBN: 9783866446793 Year: Volume: 2011,2 Pages: XXII, 268 p. DOI: 10.5445/KSP/1000023055 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
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Target Costing dient der Entwicklung wirtschaftlicher Produkte, wobei das Verfahren Schwächen und fehlende Ausgestaltungen hat. Aus diesem Grund werden Methoden und Prozessverbesserungen entwickelt, die das Target Costing erweitern und unterstützen. Die Methoden und Prozessverbesserungen werden in einem Anwendungsfall des Maschinenbaus in Bezug auf ihre Praxistauglichkeit überprüft. Es wird gezeigt, wodurch die Produktentwicklung von den neuen Methoden und Prozessverbesserungen profitiert.

PAIN - Novel targets and new technologies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193943 Year: Pages: 95 DOI: 10.3389/978-2-88919-394-3 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2015-12-03 13:02:24
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The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. This e-Book "PAIN - Novel targets and new technologies" has brought together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies across the various types of pain. This information is presented as novel research findings, short communications and review articles. The goal of this e-Book is to generate further collaborative discussion on the future and direction of pain therapies.

An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2

Authors: --- --- ---
ISBN: 9783038424130 9783038424123 Year: Pages: 320 DOI: 10.3390/books978-3-03842-413-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2017-07-12 07:57:21
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The 8th International Conference on Protein Kinase CK2 (www.uks.eu/ck2), organized by Matthias Montenarh and Claudia Götz, will be held at the Faculty of Medicine of Saarland University, in Homburg, Germany, from 6–9 September, 2016.Protein kinase CK2 is a serine/threonine kinase, which is highly conserved in evolution. Knock-out experiments have shown that this enzyme is absolutely necessary for cell viability. The enzyme is highly expressed in rapidly proliferating cells, which goes along with an elevated enzyme activity. Protein kinase CK2 is involved in a broad range of signaling pathways, regulating proliferation, differentiation, apoptosis, or senescence. Recent advances towards the characterization of the three-dimensional structure of protein kinase CK2 and its subunits will undoubtedly yield important new insights into its regulation, and the functions of CK2. Moreover, with two inhibitors of the enzyme presently in clinical phase II trials, human protein kinase CK2 has appeared as an emerging target for cancer diseases.

Communicating In School Science

Authors: ---
ISBN: 9780203974247 9781850006428 9781850006435 9781135387822 9781135387815 9781135387778 Year: DOI: 10.4324/9780203974247 Language: English
Publisher: Taylor & Francis
Subject: Education
Added to DOAB on : 2019-11-08 11:21:28
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First published in 1991. Routledge is an imprint of Taylor & Francis, an informa company.

Keywords

attainment --- target --- key --- stage --- national --- curriculum --- profile --- component --- non-threatening --- learning

Instruments and Methods for Cyclotron Produced Radioisotopes

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ISBN: 9783039282029 9783039282036 Year: Pages: 230 DOI: 10.3390/books978-3-03928-203-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-01-30 16:39:46
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The focus of this Special Issue is aimed at enhancing the discussion of Engineering Education, particularly related to technological and professional learning. In the 21st century, students face a challenging demand: they are expected to have the best scientific expertise, but also highly developed social skills and qualities like teamwork, creativity, communication, or leadership. Even though students and teachers are becoming more aware of this necessity, there is still a gap between academic life and the professional world. In this Special Edition Book, the reader can find works tackling interesting topics such as educational resources addressing students’ development of competencies, the importance of final year projects linked to professional environments, and multicultural or interdisciplinary challenges.

Keywords

cyclotron --- PET --- titanium-45 --- unconventional radionuclides --- cyclotron --- targetry --- thermal study --- recycling of [18O]-water --- enrichment grade --- fractional distillation --- azeotropic mixtures --- molecular sieve desiccant --- 165Er --- 52Mn --- irradiation --- separation --- resin --- radiometals --- heavy Rare Earth Elements (hREE) --- liquid targets --- medical cyclotron --- radiometals --- gallium-68 --- copper-64 --- copper-61 --- purification --- disposable kit --- radiopharmaceuticals --- radionuclide production --- target stations --- targetry --- 70 MeV cyclotron --- beam energy --- ion accelerator --- medical cyclotron --- ion source --- filament --- cyclotron --- medical isotopes --- SPECT --- cyclotron --- medical radioisotope production --- radioactive impurities --- cross-section --- stacked-foils --- gamma spectroscopy --- thick target yield --- Radionuclide Yield Calculator --- cyclotron target --- carbon-11 --- recoil escape --- boron nitride nanotubes --- BNNTs --- cyclotrons --- radionuclide production --- solid, liquid and gas targets --- PET --- medical isotopes --- Ga-68 --- solid target --- radioisotopes --- medical radioisotopes --- radioisotope targetry --- solid radioisotope targets --- radioisotope target processing --- medical cyclotrons --- cyclotron --- targetry --- solid target --- metal 3D-printing --- target temperature --- radiometals --- radionuclides --- radioisotopes --- medical radioisotopes --- radioisotope targetry --- solid radioisotope targets --- radioisotope target processing --- medical cyclotrons --- PET --- medical isotopes --- solid target system --- radioisotope production --- Molybdenum-100 --- cyclotron --- molybdenum material recovery --- actinium-225 --- thorium --- spallation --- proton target --- ANSYS --- targeted alpha therapy --- cyclotron --- stack-foil --- monitor reaction --- cyclotron solid target --- radioisotope production --- magnetron sputtering --- thick film deposition --- cyclotron --- powder target --- thermal study --- vortex target --- Gallium-68 --- Technetium-99m --- medical Sc radioisotopes --- radioisotope production --- thick target yield measurements --- cross-section reconstruction --- numerical analysis --- cyclotrons --- targets --- target chemistry --- radioisotopes --- theranostics

Phenotypic screening in the 21st century

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194698 Year: Pages: 67 DOI: 10.3389/978-2-88919-469-8 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of target-based drug discovery as an optimal strategy for all disease states. For monogenic diseases, target-based approaches may be well-suited to the identification of novel therapies. Most diseases, however, are caused by a combination of several genetic and environmental factors and are likely to require simultaneous modulation of multiple molecular targets/pathways for successful treatment. For such diseases, reductionist approaches focusing on individual targets rather than biological networks are unlikely to succeed and new drug development strategies are required. In search of more successful approaches, the pharmaceutical industry is moving towards phenotypic screening beyond individual genes/targets. However, this requires rethinking of diseases and drug discovery approaches from a network and systems biology perspective. Since returning to the pre-genomics era of screening drug candidates in laborious animal models is not a feasible solution, the industry needs to evolve a new paradigm of phenotypic drug discovery within the context of systems biology. Such a paradigm must combine physiologically and disease relevant biological substrates with sufficient throughput, operational simplicity and statistical vigour. Biomarker strategies for translational medicine, as well as preclinical safety and selectivity assessments, would also need to be revised to adapt to the target agnostic style. This focused issue aims to discuss strategies, key concepts and technologies related to systems-based approaches in drug development. Design and implementation of innovative biological assays, featuring multiple target strategies, and rational drug design in the absence of target knowledge during the early drug discovery are illustrated with examples. Specific topics include: • The need for systems-based approaches in drug development • Phenotypic screening strategies • Compound libraries (natural product inspired compound collections) • Target deconvolution and identification • Target agnostic lead discovery and optimization • Multi-target approaches and decoding the phenotype (understanding biological interactions and multiscale systems modelling) • Translational aspects • Early evaluation of selectivity and safety in a target agnostic manner

Polarimetric Radar for Automotive Applications

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Book Series: Karlsruher Forschungsberichte aus dem Institut für Hochfrequenztechnik und Elektronik ISSN: 18684696 ISBN: 9783731508885 Year: Volume: 90 Pages: IX, 159 p. DOI: 10.5445/KSP/1000090003 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:02
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Current automotive radar sensors prove to be a weather robust and low-cost solution, but are suffering from low resolution and are not capable of classifying detected targets. However, for future applications like autonomous driving, such features are becoming ever increasingly important. On the basis of successful state-of-the-art applications, this work presents the first in-depth analysis and ground-breaking, novel results of polarimetric millimeter wave radars for automotive applications.

Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation

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ISBN: 9788376560564 Year: Pages: 368 DOI: 10.2478/9788376560564 Language: English
Publisher: De Gruyter
Subject: Biochemistry
Added to DOAB on : 2014-03-05 13:31:51
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H4R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199280 Year: Pages: 146 DOI: 10.3389/978-2-88919-928-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Botany
Added to DOAB on : 2016-01-19 14:05:46
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Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradation. In contrast to animal systems, which are nurtured from drug research, the systematic development of novel bioactive small molecules as research tools for plant systems is a largely underexplored research area. This is surprising since bioactive small molecules bear great potential for generating new, powerful tools for dissecting diverse biological processes. In particular, when small molecules are integrated into genetic strategies (thereby defining “chemical genetics”), they may help to circumvent inherent problems of classical (forward) genetics. There are now clear examples of important, fundamental discoveries originating from plant chemical genetics that demonstrate the power, but not yet fully exploited potential, of this experimental approach. These include the unraveling of molecular mechanisms and critical steps in hormone signaling, activation of defense reactions and dynamic intracellular processes. The intention of this Research Topic of Frontiers in Plant Physiology is to summarize the current status of research at the interface between chemistry and biology and to identify future research challenges. The research topic covers diverse aspects of plant chemical biology, including the identification of bioactive small molecules through screening processes from chemical libraries and natural sources, which rely on robust and quantitative high-throughput bioassays, the critical evaluation and characterization of the compound’s activity (selectivity) and, ultimately, the identification of its protein target(s) and mode-of-action, which is yet the biggest challenge of all. Such well-characterized, selective chemicals are attractive tools for basic research, allowing the functional dissection of plant signaling processes, or for applied purposes, if designed for protection of crop plants from disease. New methods and data mining tools for assessing the bioactivity profile of compounds, exploring the chemical space for structure–function relationships, and comprehensive chemical fingerprinting (metabolomics) are also important strategies in plant chemical biology. In addition, there is a continuing need for diverse target-specific bioprobes that help profiling enzymatic activities or selectively label protein complexes or cellular compartments. To achieve these goals and to add suitable probes and methods to the experimental toolbox, plant biologists need to closely cooperate with synthetic chemists. The development of such tailored chemicals that beyond application in basic research can modify traits of crop plants or target specific classes of weeds or pests by collaboration of applied and academic research groups may provide a bright future for plant chemical biology. The current Research Topic covers the breadth of the field by presenting original research articles, methods papers, reviews, perspectives and opinions.

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