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Cellular Entry of Binary and Pore-Forming Bacterial Toxins

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ISBN: 9783038427049 9783038427032 Year: Pages: 128 DOI: 10.3390/books978-3-03842-703-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-02-08 13:26:54
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Abstract

Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein–lipid and protein–protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification.This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues.

Novel Smart Textiles

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ISBN: 9783039285709 / 9783039285716 Year: Pages: 230 DOI: 10.3390/books978-3-03928-571-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Arts in general
Added to DOAB on : 2020-06-09 16:38:57
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The sensing, adapting, responding, multifunctionality, low energy, small size and weight, ease of forming, and low-cost attributes of smart textiles and their multidisciplinary scope offer numerous end uses in medical, sports and fitness, military, fashion, automotive, aerospace, the built environment, and energy industries. The research and development on these new and high-value materials cross scientific boundaries, redefine material science design and engineering, and enhance quality of life and our environment. “Novel Smart Textiles” is a focused Special Issue that reports the latest research of this field and facilitates dissemination, networking, discussion, and debate.

Keywords

e-textile --- metamaterials --- transmission line --- wearable --- split ring resonator --- dye-sensitized solar cell (DSSC) --- polyacrylonitrile (PAN) --- nanofiber mat --- electrospinning --- PEDOT:PSS --- dye-sensitized solar cell --- half-textile --- spectral analysis --- parameter identification --- equivalent circuit --- black-box --- grey-box --- power spectral density --- optimization --- analytical model --- electromagnetic shielding effectiveness --- electric properties --- fabric --- woven textiles --- carbon nanomaterials --- smart fabrics --- in-line monitoring --- polymeric composites --- carbon nanotubes --- reduced graphene oxide --- textile electrode --- ECG --- motion sensor --- skin-electrode impedance --- electrically conductive textiles --- polymers --- smart textiles --- surface area evaluation --- microencapsulation --- biofunctional --- drug-delivery --- textile-based stretch sensors --- stitch structure --- wearable stretch sensor --- conductive thread --- conductivity --- metal flake --- coating --- e-textile --- encapsulation --- durability --- stiffness --- textile/polymer composite --- stretchable electronics --- smart textiles --- mechanical and electrical properties --- quasi-static and cyclic mechanical loading --- life-time expectancy --- smart textile --- thermal textile pixel --- thermal communication --- non-auditory and nonvisual communication --- thermal conductivity --- Peltier element --- SMART pattern-changing fabric --- pattern effect --- visual response --- visual brain --- event-related potential (ERP) --- psychotextiles --- art and design --- smart textiles --- textile sensors --- e-textiles --- visual brain --- thermal textile pixels --- stretchable electronics --- conductive textiles --- wearables --- stitch-based sensors --- biofunctional textiles --- ECG --- hybrid electrodes --- motion tracking --- carbon nanotextiles --- composites --- EMS textiles --- electrospun solar cells --- embroidered e-textiles --- targeted delivery --- psychotextiles --- energy harvesting --- multifunctional

Plant Natural Products for Human Health

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ISBN: 9783038977124 Year: Pages: 514 DOI: 10.3390/books978-3-03897-713-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2019-04-05 10:34:31
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Abstract

Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs.This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Keywords

heat-process --- onion --- calorie restriction --- Amadori rearrangement compounds --- hyperglycemia --- A549 cells --- hinokitiol --- MMPs --- p53/Bax --- antioxidant enzymes --- caspases --- migration --- cannabinoid type 1 receptor --- endoplasmic reticulum stress --- gluconeogenesis --- gomisin N --- lipogenesis --- insulin resistance --- garlic --- ischemia --- heme oxygenase --- reperfusion --- heart --- Keap1 --- Nrf2 --- Neuroprotective --- PC12 cells --- PhGs --- anti-malaria activity --- plants --- natural products --- ethnopharmacology --- Plasmodium parasites --- copaiba --- oleoresin --- essential oil --- sesquiterpenoids --- diterpenoids --- biological activity --- molecular targets --- Astragali Radix --- astragaloside IV --- genistein --- mitochondrial bioenergetics --- oxygen consumption rate --- natural products --- drug design and development --- innovation --- automation --- computational softwares --- bioinformatics --- precision medicine --- omics --- global health --- sweet orange --- bitter orange --- neroli --- orange petitgrain --- mandarin --- lemon --- lime --- grapefruit --- bergamot --- yuzu --- kumquat --- cannabigerol --- Cannabis sativa --- neuroinflammation --- oxidative stress --- phytocannabinoid --- iridoids --- nuclear factor-kappaB --- mitogen-activated protein kinase --- anti-inflammation --- Ziziphus jujuba --- triterpenic acids --- pharmacokinetic study --- acute liver injury --- A? --- AD --- lychee seed --- neuroinflammation --- catechin --- procyanidin A2 --- apoptosis --- cinnamamides --- antistaphylococcal activity --- time-kill assay --- biofilm --- antitubercular activity --- MTT assay --- antifungal activity --- PET inhibition --- toxicity --- structure–activity relationship --- bleeding time --- flavonoid --- morin hydrate --- OH· free radical --- platelet activation --- protein kinase --- thromboembolism --- Glycyrrhiza uralensis --- prenylated flavonoids --- antiproliferation --- differentiation --- melanoma cell --- adjuvant-induced arthritis --- arthritis --- celastrol --- curcumin --- dietary supplements --- EGCG --- green tea --- inflammation --- liposomes --- microbiome --- nanoparticles --- natural products --- resveratrol --- rheumatoid arthritis --- targeted delivery --- traditional medicine --- Tripterygium wilfordii --- triptolide --- Penthorum chinense Pursh --- NAFLD --- hepatic steatosis --- flavonoids --- SIRT1 --- AMPK --- dihydromyricetin --- myocardial hypertrophy --- oxidative stress --- sirtuin 3 --- ginseng --- human-hair-follicle dermal papilla cells --- WNT/?-catenin --- Shh/Gli --- TGF-? --- BMP/Smad --- mouse-hair growth --- Panax notoginseng saponins --- aspirin --- HepaRG cells --- herb–drug interactions --- P. eryngii --- glucans --- inflammation --- inflammatory bowel disease --- medicinal plants --- phytochemicals --- scoulerine --- bergapten --- immunomodulator --- adjuvant --- cytoxicity --- dendritic cells --- immune modulation --- APAP --- acetaminophen --- hepatotoxicity --- hpatoprotection --- paracetamol --- animals --- preclinical studies --- natural products --- small molecules --- phytochemicals --- plants --- fucoidan --- acetaminophen --- Nrf2 --- oxidative stress --- hepatotoxicity --- plant natural product --- drug discovery --- human health

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