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Kaposi's Sarcoma-Associated Herpesvirus

ISBN: 9783038420774 9783038420767 Year: Pages: 356 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-10-22 09:09:45
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The discovery of KSHV in 1994 was a historical landmark in tumor virology and human cancer research. Its subsequent identification as a cause of Kaposi sarcoma and in association with primary effusion lymphoma and multicentric Castleman disease soon attracted up to hundreds of research laboratories and thousands of virologists and oncologists to switch their research directions. To date, PubMed has collected nearly 5000 papers on KSHV from numerous journal publications in the world. These studies reiterate that the global fight against human cancers will continue to receive great support from our tremendous efforts in searching for new tumor-causing viruses and in understanding the basic biology of tumor viruses. To celebrate the 20th years of KSHV discovery, I am very proud to be an invited Guest Editor for a special issue on KSHV in the journal "Viruses" and happy to assemble all published articles from the special issue into this book, Kaposi Sarcoma Associated Herpesvirus. The collected articles cover almost all aspects of KSHV, including updated reviews and research articles on KSHV epidemiology and transmission, KSHV interaction with host cell receptors and cell entry, KSHV latency and latency-associated nuclear antigen (LANA), molecular biology of KSHV lytic reactivation and lytic switch control by KSHV ORF50 and other factors, KSHV post-transcriptional regulator ORF57, molecular biology of KSHV polyadenylated nuclear RNA (PAN RNA) and PAN as a lncRNA in epigenetic gene regulation of KSHV, viral mimics of cellular genes in KSHV infection and disease, KSHV targeted therapy, KSHV miRNAs and vGPCR, etc. In particular, I am greatly honored to have Yuan Chang and Patrick Moore to mark the first 20 years of KSHV research by recounting the historical stories leading to their astonish discovery and Science publication of KSHV that has led us where we are today. The book is also intended to assist Medical students and residents, dermatologists, hematologist, oncologists, and other related specialties to understand what we have known about KSHV and its infections and pathogenesis.

Vitamin D and Human Health

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ISBN: 9783038975861 / 9783038975878 Year: Pages: 306 DOI: 10.3390/books978-3-03897-587-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2019-02-21 10:04:11
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Over the past decades, researchers have gathered data demonstrating that vitamin D and its metabolites possess activities far beyond the classic regulation of calcium–phosphate homeostasis. It is now well established that vitamin D is essential for the proper functioning of the musculoskeletal, cardiovascular, nervous, and immune systems. Furthermore, vitamin D and its analogs were shown to regulate proliferation and differentiation of keratinocyte, immune cells, and numerous cancer-derived cells, both in vivo and in vitro. On the other hand, population base studies have provided evidence that global vitamin D deficiency is correlated with the occurrence and aggravation of symptoms of skeletal, cardiovascular autoimmune, and skin disease; infections; metabolic and cognitive disorders; multiple types of cancers; as well as overall mortality. This Special Issue of International Journal of Molecular Sciences, entitled “Vitamin D and Human Health”, summarizes recent advances in our understanding of pleiotropic activity of vitamin D with a focus on its protective role against cancer, hypertension, viral infections, and neurological diseases, as well as its impact on the immune system and mitochondria. Furthermore, eight research papers provide new insight into vitamin D research and highlight new directions and targets in the prevention and treatment of human diseases.

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