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Drug-Acceptor Interactions - Modeling theoretical tools to test and evaluate experimental equilibrium effects

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ISBN: 9789197707107 9789197707114 Language: English
Publisher: Co-Action Publishing
Subject: Medicine (General)
Added to DOAB on : 2011-11-18 23:34:43
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Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state.The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze ones own data.

Keywords

Drugs --- therapy

Occupational Therapy - Occupation Focused Holistic Practice in Rehabilitation

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ISBN: 9789535133216 9789535133223 Year: Pages: 232 DOI: 10.5772/65138 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:50

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This new book presents the growing occupational therapy knowledge and clinical practice. Occupational therapy, as a health profession, is concerned with preserving well-being through occupations, and its main goal is to help people participate in the activities of daily living. This is achieved by working with people to improve their ability to engage in the occupations they want to engage in or by changing the occupation or the environment to better support their occupational engagement. The topic of the book has been structured on occupational therapy framework and reflects new research, techniques, and occupational therapy trends. This useful book will help students, occupational therapy educators, and professionals to connect occupational therapy theories and the evidence-based clinical practice.

Occupational Therapy - Therapeutic and Creative Use of Activity

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ISBN: 9781789844108 9781789844115 Year: Pages: 136 DOI: 10.5772/intechopen.72549 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:52

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Occupational therapy is a health care specialty with a deep focus on client-centered and holistic rehabilitation to improve the individual's occupational performance, quality of life and well-being through participation in meaningful and purposeful activities. This new book presents the importance of the therapeutic and creative use of activity in different populations, which is one of the core components of occupational therapy. Rehabilitation, rehabilitation delivery and outcomes are affected by recent changes in the meaning of health and social values. This resulted in an increasing necessity for therapeutic therapy, as well as creative use of activity in occupational therapy. This book focuses on recent advances in occupational therapy and reviews current practical guidelines. It introduces updated knowledge and skills for children, adults and the communities, including physical, mental, social, sensory, behavioral, environmental and community-based interventions to prevent, promote and improve activity use. The book will be relevant to occupational therapists, speech and language therapists, physical therapists, psychiatrists, psychologists, social workers and all the members of interdisciplinary rehabilitation team care workers.

Onkologie für die Palliativmedizin

Authors: --- ---
ISBN: 9783863952297 Year: Language: German
Publisher: Universitätsverlag Göttingen
Subject: Medicine (General)
Added to DOAB on : 2016-06-21 11:02:24
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Über 90% der in der spezialisierten Palliativversorgung betreuten Patienten leiden an einer Krebserkrankung. Sowohl der Impuls einer frühzeitigen, bedürfnisorientierten palliativmedizinischen Mitbehandlung als auch die erheblichen Weiterentwicklungen einer (zunehmend molekular definierten) Onkologie erfordern, dass auch die in der Palliativversorgung Tätigen ein Grundverständnis von Tumorbiologie, von modernen onkologischen Therapiekonzepten und von supportivtherapeutischen Möglichkeiten haben. Dieses Buch möchte dieses Grundverständnis von Krebs und onkologischer Behandlung in einer auch für Nicht-Onkologen verständlichen Form vermitteln und richtet sich vor allem an jene, die in der palliativmedizinischen Betreuung krebskranker Menschen involviert sind: Palliativärzte, Palliativpflegende, aber auch Haus- und Fachärzte, Physiotherapeuten, Seelsorger, Psychotherapeuten und viele mehr. Es will kein Lehrbuch der Onkologie ersetzen, sondern eine praxisorientierte, therapie- und versorgungsrelevante Hilfestellung im (palliativ-)medizinischen Arbeitsalltag sein – dort, wo es um eine umfassende Unterstützung von Krebspatienten geht. Das Buch ist ein Projekt der „AG Interdisziplinäre Onkologie“ der Deutschen Gesellschaft für Palliativmedizin (DGP).

Keywords

cancer --- medicine --- therapy

Chapter 5 Mercury Tonics (Rasāyana) in Sanskrit Medical Literature (Book chapter)

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ISBN: 9781781791288 9781781791288 9781781791295 9781781794364 9781781794371 Year: Pages: 21 Language: English
Publisher: Equinox Grant: H2020 European Research Council - 639363
Subject: Medicine (General) --- History
Added to DOAB on : 2019-01-15 13:34:35
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This chapter will provide a brief survey of the uses of mercury preparations&#xD;in rasāyana therapy, discussing their position within rejuvenation&#xD;therapy in regard to other rasāyana formulations and exploring their link&#xD;with Indian alchemical traditions.

Keywords

History --- Indian medicine --- therapy

Computational Modelling of the Steps Involved in Photodynamic Therapy (Book chapter)

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ISBN: 9789535104469 Year: DOI: 10.5772/37654 Language: English
Publisher: IntechOpen Grant: FP7 Ideas: European Research Council - 258990
Subject: Science (General)
Added to DOAB on : 2019-01-17 11:47:59
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Photodynamic therapy (PDT) is a branch of phototherapy that has seen a surge of interest in the last few decades, due to its potential in the treatment of various cancers, infections and&#xD;&#xD;heart disease.(Bonnett, 2000) This chapter aims to give an overview of the various&#xD;&#xD;photochemical steps involved in PDT as a cancer therapy, and in particular the challenges&#xD;&#xD;and insight gained from their theoretical description. After a brief review of PDT in general,&#xD;&#xD;in a biological and chemical context, the photochemical steps involved will be discussed,&#xD;&#xD;detailing the computational techniques required to model these chemical pathways&#xD;&#xD;theoretically. We will detail the methodologies that can currently be applied, as well as their&#xD;&#xD;limitations of use at present, and areas requiring further development.

Ostranenie: On Shame and Knowing

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ISBN: 9780615744797 Year: Pages: 50 DOI: 10.21983/P3.0019.1.00 Language: English
Publisher: punctum books
Subject: History
Added to DOAB on : 2019-06-12 09:24:45
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Ostranenie, the term for defamiliarization introduced by Russian writer and critic Victor Shklovsky, means, among other things, to see in strangeness. To see in strangeness is to participate in an illusion that is more real than real. It may be achieved by (re)presenting the surface as the substance, the play as the thing, or by examining (from exigere: to drive out) what is present before one’s eyes. Ultimately, ostranenie means confessing one’s complicity in making known what is known. M.H. Bowker’s Ostranenie: On Shame and Knowing is a meditation upon the moment of a mother’s death: a moment of defamiliarization in several senses. The body of the work consists of footnotes which elaborate, by exegesis, by parataxis, and sometimes by surprise, the intimate and often hidden relationships between parent and child, illusion and knowledge, shame and loss. These elaborations raise questions about the power of the familiar, the limitations of discursive thought, and the paradoxical nature of the interpersonal, political, and spiritual bargains we make for the sake of security and freedom.

Advances in the Prevention and Management of Obesity and Eating Disorders

Authors: ---
ISBN: 9783038428534 9783038428541 Year: Pages: VIII, 192 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-05-18 12:02:38
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Obesity and eating disorders remain major public health concerns worldwide that often co-exist. While we are far from having definitive solutions, scientific insights into the prevention and management of obesity and eating disorders have developed significantly in recent years. This research has been stimulated by the continuous challenge of reducing the global burden of obesity and its commonly associated health complications, as well as the life-threatening characteristics of eating disorders. Looking towards better solutions for these pressing public health concerns, this book addresses recent scientific findings regarding the prevention and management of obesity and eating disorders. It reports on cognition and mental health in people with obesity, as well as on food addiction, co-morbidities of eating disorders, cultural aspects of eating, intermittent dietary energy restriction as a treatment for overweight or obesity, factors influencing the adherence to dietary treatments for overweight and obesity, philosophies underpinning dietary practices, treatment of eating disorders in men, cognitive remediation therapy for anorexia nervosa, and online or virtual interventions for weight management or bulimia nervosa. This book includes culturally diverse findings from research groups around the world (e.g. Australia, UK, Norway, Brazil), and is informative for healthcare professionals and researchers working in the fields of obesity and/or eating disorders.

New therapeutic targets for human placental angiogenesis diseases

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194612 Year: Pages: 113 DOI: 10.3389/978-2-88919-461-2 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and activity of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), adenosine and nitric oxide, associates with compromised secretion and activity of anti-angiogenic factors such as soluble receptor of VEGF (sFlt-1), thrombospondin 2, endostatin among others. More recent evidences include the participation of endothelial progenitor cells (EPC), which circulating number is reduced infeto-placental circulation in pregnancies such as pre-eclampsia. Despite this knowledge, therapies for placental angiogenesis recovery during pathological pregnancies are far to be tested. However, from the cardiovascular field, it has been described the administration of EPC, alone or used as gene-transfer therapy; or it has been described the potential role of statins (HMGCoA inhibitors), or angiotensin-converter enzyme (ACE) inhibitors for enhancing angiogenesis. Finally, feto-placental tissue is an exceptional source of progenitor and stem cells, which could be used for treated other human diseases such as stroke, myocardial infarction, hypertension, or even cancer. In this research topic, authors highlight physiopatological and clinical importance of the impaired placental angiogenesis, and suggest potential targets for developing innovative therapies.

Hallucinations: New Interventions Supporting People with Distressing Voices and/or Visions

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450077 Year: Pages: 106 DOI: 10.3389/978-2-88945-007-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2018-02-27 16:16:44
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Hallucinations can occur across the five sensory modalities (auditory, visual, olfactory, tactile, and gustatory). Whilst they have the potential to be benign or even highly valued, they can often be devastating experiences associated with distress, impaired social and occupational functioning, self-harm and suicide. Those who experience hallucinations in this latter manner may do so within the context of a wide range of psychiatric diagnoses, including schizophrenia, bipolar disorder, borderline personality disorder, and post-traumatic stress disorder. The only routinely available interventions for people distressed by hallucinations are antipsychotic drugs, which date from the introduction of chlorpromazine in the 1950s, and manualized cognitive behavioral therapy, which originated in the 1990s. These interventions do not help all people distressed by hallucinations, and in the case of antipsychotic medication, come with notable side-effects. There has hence been great interest in new interventions to support people distressed by hallucinations. The goal of this Frontiers Research Topic is to present a collection of papers on new developments in clinical interventions for those distressed by hallucinations. In the psychiatric condition that remains most strongly associated with hallucinations, schizophrenia, the majority (~70%) of people will have experienced hallucinations in the auditory modality, approximately a third will have experienced visual hallucinations, and a smaller minority will have experienced hallucinations in other modalities. Consistent with this prevalence, this collection focusses on auditory and visual hallucinations. This is not to minimise the potential distress that can occur from hallucinations in other modalities. For example, tactile hallucinations, particularly when stemming from earlier experiences of sexual abuse, can be highly distressing, and improved ways to help sufferers of such experiences are also needed. In summary, this collection aims to result in an interdisciplinary collection of papers which will appeal to a wide readership, spanning all with an interest in this area.

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