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Significance of antigen and epitope specificity in tuberculosis

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194513 Year: Pages: 119 DOI: 10.3389/978-2-88919-451-3 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2016-02-05 17:24:33
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Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis.

Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 DOI: 10.1007/978-3-319-19132-4 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2016-03-15 10:53:40
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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

The Teacher and the Superintendent: Native Schooling in the Alaskan Interior, 1904-1918

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Book Series: Our Lives: Diary, Memoir, and Letters ISSN: 19216661 ISBN: 9781927356500 9781927356517 9781927356524 9781927356982 Year: Pages: 440 DOI: 10.15215/aupress/9781927356500.01 Language: English
Publisher: Athabasca University Press
Subject: Education
Added to DOAB on : 2016-08-10 20:09:15
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From its inception in 1885, the Alaska School Service was charged with the assimilation of Alaskan Native children into mainstream American values and ways of life. Working in the missions and schools along the Yukon River were George E. Boulter and Alice Green, his future wife. Boulter, a Londoner originally drawn to the Klondike, had begun teaching in 1905 and by 1910 had been promoted to superintendent of schools for the Upper Yukon District. In 1907, Green left a comfortable family life in New Orleans to answer the “call to serve” in the Episcopal mission boarding schools for Native children at Anvik and Nenana, where she occupied the position of government teacher. As school superintendent, Boulter wrote frequently to his superiors in Seattle and Washington, DC, to discuss numerous administrative matters and to report on problems and conditions overall.From 1906 to 1918, Green kept a personal journal—hitherto in private possession—in which she reflected on her professional duties and her domestic life in Alaska. Collected in The Teacher and the Superintendent are Boulter’s letters and Green’s diary. Together, their vivid, first- hand impressions bespeak the earnest but paternalistic beliefs of those who lived and worked in immensely isolated regions, seeking to bring Christianity and “civilized” values to the Native children in their care. Beyond shedding private light on the missionary spirit, however, Boulter and Green have also left us an invaluable account of the daily conflicts that occurred between church and government and of the many injustices suffered by the Native population in the face of the misguided efforts of both institutions.

Reassessing Twenty Years of Vaccine Development Against Tuberculosis

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454464 Year: Pages: 110 DOI: 10.3389/978-2-88945-446-4 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2018-11-16 17:17:57
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Tuberculosis (TB) remains the prime bacterial infection worldwide with 10.4 million infections and a death toll of 1.7 million people in 2016 according to WHO statistics. Tuberculosis is caused by members of the Mycobacterium tuberculosis complex, facultative intracellular bacteria able to thrive within otherwise potent innate defense cells, the macrophages. In a world of increasing numbers of infections with drug resistant M. tuberculosis strains, the daunting race between developing new therapeutics and emerging resistant strains will hardly produce a winner. This cycle can only be broken by enhancing population wide immune control through a better vaccine as the only one currently in use, M. bovis Bacillus Calmette Guerin (BCG). The protective efficacy of BCG against pulmonary tuberculosis in all age groups is dissatisfying and geographically highly diverse with the tropical areas showing the lowest efficacy rates. Despite worldwide vaccination coverage, the impact of BCG on the steep decrease of tuberculosis incidence rates in the developed world seems therefore questionable and can rather be attributed to improved social, housing and nutritional conditions, better health care, surveillance and treatment systems. The last 15 years saw tremendous efforts to improve vaccination strategies against tuberculosis. Different paths of vaccine approaches were followed including genetically improved BCG strains, attenuated M. tuberculosis variants, recombinant viral vectors and subunit vaccine candidates combined with novel more potent adjuvants. With the first novel vaccine candidates being evaluated in clinical phases II and III and initial results chastening the expectations, a critical reassessment of all candidates is inevitable. Here, we assembled experts to review and assess the current status of novel anti-tuberculosis vaccine candidates, their efficacy and prospects for implementation as well as the pitfalls and possible measures for improvement.

Epidemiology (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Pathogenesis (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

References (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Treatment (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:46

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Abstract

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Diagnosis (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:47

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Abstract

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Prevention (Book chapter)

Book title: Tuberculosis in Adults and Children

Authors: --- --- ---
Book Series: SpringerBriefs in Public Health ISBN: 9783319191317 Year: Pages: 66 Language: English
Publisher: Springer Grant: Wellcome Trust - 089276
Subject: Internal medicine
Added to DOAB on : 2019-01-15 13:34:47

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Abstract

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

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