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Process Design, Integration, and Intensification

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ISBN: 9783038979821 / 9783038979838 Year: Pages: 188 DOI: 10.3390/books978-3-03897-983-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-06-26 08:44:06
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With the growing emphasis on enhancing the sustainability and efficiency of industrial plants, process integration and intensification are gaining additional interest throughout the chemical engineering community. Some of the hallmarks of process integration and intensification include a holistic perspective in design, and the enhancement of material and energy intensity. The techniques are applicable for individual unit operations, multiple units, a whole industrial facility, or even a cluster of industrial plants. This book aims to cover recent advances in the development and application of process integration and intensification. Specific applications are reported for hydraulic fracturing, palm oil milling processes, desalination, reactive distillation, reaction network, adsorption processes, herbal medicine extraction, as well as process control.

Towards Mechanism-based Treatments for Fragile X Syndrome

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ISBN: 9783039215058 / 9783039215065 Year: Pages: 250 DOI: 10.3390/books978-3-03921-506-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.

Keywords

fragile X syndrome --- clinical trials --- targeted treatments --- drug development --- fragile X syndrome --- clinical trials --- treatment development --- best practices --- fragile X syndrome --- newborn screening --- early identification --- fragile X syndrome --- X chromosome --- females --- FMR1 --- anxiety --- avoidance --- cognition --- behavior --- brain --- Fragile X --- FMRP --- Fxr2 --- Fmr1 --- fragile X syndrome --- executive function --- working memory --- set-shifting --- cognitive flexibility --- inhibitory control --- attention --- planning --- processing speed --- Fragile X syndrome 1 --- Fragile X-associated Tremor/Ataxia Syndrome 2 --- CRISPR 3 --- Trinucleotide Repeat 4 --- Gene editing --- fragile X syndrome --- FMR1 gene --- voice of the person --- voice of the patient --- characteristics that have the greatest impact --- developmental disorders --- fragile X syndrome --- language development --- automated vocal analysis --- adeno-associated virus --- autism spectrum disorders --- cerebral spinal fluid --- fragile X mental retardation protein --- neurodevelopmental disorders --- viral vector --- fragile X syndrome --- gene reactivation --- RNA:DNA hybrid --- FMRP --- histone methylation --- DNA methylation --- FMR1 --- PRC2 --- fragile X syndrome --- unstable repeat diseases --- epigenetic gene silencing --- DNA methylation --- repeat instability --- pluripotent stem cells --- CGG Repeat Expansion Disease --- DNA instability --- expansion --- contraction --- mismatch repair (MMR) --- base excision repair (BER) --- transcription coupled repair (TCR) --- double-strand break repair (DSBR) --- Non-homologous end-joining (NHEJ) --- mosaicism --- protein synthesis --- Fragile X Syndrome --- biomarker --- iPSC --- fibroblast --- lymphoblast --- fragile X syndrome --- molecular biomarkers --- FMR1 --- FMRP --- intellectual disability --- Fmr1 KO mouse --- ASD --- n/a

Fluid Flow in Fractured Porous Media

Authors: ---
ISBN: 9783039214235 / 9783039214242 Year: Volume: 1 Pages: 578 DOI: 10.3390/books978-3-03921-424-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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The fluid flow in fracture porous media plays a significant role in the assessment of deep underground reservoirs, such as through CO2 sequestration, enhanced oil recovery, and geothermal energy development. Many methods have been employed—from laboratory experimentation to theoretical analysis and numerical simulations—and allowed for many useful conclusions. This Special Issue aims to report on the current advances related to this topic. This collection of 58 papers represents a wide variety of topics, including on granite permeability investigation, grouting, coal mining, roadway, and concrete, to name but a few. We sincerely hope that the papers published in this Special Issue will be an invaluable resource for our readers.

Keywords

scanning electron microscope (SEM) images --- permeability --- high temperature --- Darcy’s law --- confining pressures --- chemical grouts --- grain size of sand --- initial water contained in sand --- grouted sand --- macroscopic mechanical behaviors --- microstructure characteristics --- ductile failure --- gas concentration --- gob-side entry retaining (GER) --- limestone roof --- roof-cutting resistance --- roadside backfill body (RBB) --- solid backfill coal mining --- goaf --- water soaked height --- loose gangue backfill material --- deformation --- crushing ratio --- fracture grouting --- cement–silicate grout --- geophysical prospecting --- seepage --- Yellow River Embankment --- contiguous seams --- water-dripping roadway --- roadway deformation --- bolt support --- pervious concrete --- permeability coefficient --- porosity --- pore distribution characteristics --- strength --- soil–structure interface --- internal erosion --- critical hydraulic gradient --- orthogonal tests --- Pseudo Steady-State (PPS) constant --- finite-conductivity fracture --- conductivity-influence function --- normalized conductivity-influence function --- circular closed reservoir --- glutenite --- gravel --- hydraulic fracture --- numerical simulation --- propagation --- glauberite cavern for storing oil &amp --- gas --- thermal-hydrological-chemical interactions --- temperature --- brine concentration --- microstructure --- micro-CT --- damage --- cyclic heating and cooling --- physical and mechanical parameters --- failure mode --- acoustic emission --- anisotropy --- bedding plane orientation --- coal --- gas --- adsorption–desorption --- laboratory experiment --- pore pressure --- hydro-mechanical coupling --- fracture closure --- constitutive model --- effective stress --- debris flow --- dynamic characteristics --- numerical analysis --- debris-resisting barriers --- coal measures sandstone --- creep characteristics --- seepage pressure --- seepage-creep --- microscopic morphology --- Darcy flow --- heterogeneity --- numerical manifold method --- high-order --- refraction law --- hydraulic fracture network --- cohesive element method --- coal seams --- fracture propagation --- discontinuous natural fracture --- secondary fracture --- fault water inrush --- coupled THM model --- nonlinear flow in fractured porous media --- numerical model --- warning levels of fault water inrush --- bentonite-sand mixtures --- differential settlement --- deformation --- hydraulic conductivity --- crack --- geogrid --- enhanced permeability --- deviatoric stress --- mechanical behavior transition --- CH4 seepage --- volumetric strain --- strain-based percolation model --- rock-soil mechanics --- soft filling medium --- segmented grouting --- split grouting --- model experiment --- reinforcement mechanism --- longwall mining --- gob behaviors --- stress relief --- permeability --- gas drainage --- hard and thick magmatic rocks --- orthogonal ratio test --- similar simulation --- fracture --- bed separation --- disaster-causing mechanism --- artificial joint rock --- shear-flow coupled test --- hydraulic aperture --- roughness --- seepage pressure --- mixing --- conservative solute --- fractal --- roughness --- fracture --- transversely isotropic rocks --- failure mechanism --- particle flow modeling --- interface --- n/a --- fractured porous rock mass --- grouting experiment --- visualization system --- flow law --- layered progressive grouting --- sandstone and mudstone particles --- rheological deformation --- segmented rheological model --- rheological limit strain --- rheological test --- water-rock interaction --- dry-wet cycles --- slope stability --- laboratory experiment --- mechanical properties --- Xinjiang --- land reclamation --- management period --- soil particle size --- fluid flow in reclaimed soil --- effluents --- soil properties --- cohesive soils --- contamination --- time variation --- stabilization --- mixer --- viscoelastic fluid --- pore structure --- orthogonal test --- fluid–solid coupling theory --- similar-material --- regression equation --- optimum proportioning --- hydraulic fracturing --- gas fracturing --- oriented perforation --- fracture propagation --- damage mechanics --- fluid viscosity --- CO2 flooding --- supercritical CO2 --- CO2 geological storage --- tight sandstone gas reservoirs --- enhanced gas recovery --- flotation --- coal particle --- collision angle --- initial settlement position --- particle velocity --- adhesion efficiency --- green mining --- paste-like slurry --- XRD --- intelligent torque rheometer --- on-site monitoring --- cyclic wetting-drying --- deterioration --- sandstone --- mudstone --- elastic modulus --- uniaxial compressive strength --- permeability characteristics --- grading broken gangue --- compressive stress --- compression deformation --- mine shaft --- alternate strata --- surrounding rock --- shaft lining --- relief excavation --- consolidation process --- unsaturated soil --- semi-analytical solution --- impeded drainage boundary --- excess pore-pressures --- coalbed methane (CBM) --- soft coal masses --- pore structure --- fractal pore characteristics --- hydraulic fractures --- PPCZ --- multitude parameters --- propagation pattern --- stress interference --- naturally fracture --- filtration effects --- grout penetration --- unified pipe-network method --- two-phase flow --- fractured porous medium --- new cementitious material --- cement-based paste discharge --- XRD --- TG/DTG --- SEM --- MIP --- mechanical behaviors --- rock fracture --- shear-flow coupled test --- constant normal stiffness conditions --- transmissivity --- hydraulic aperture --- water inrush prevention --- backfill mining --- strata movement --- ground pressure --- floor failure depth --- water–rock interaction --- degradation mechanism --- mixed mode fracture resistance --- fracture criteria --- T-stress --- hydro-power --- high-steep slope --- fractured rock --- permeability --- seepage control --- gas-bearing coal --- electrical potential --- charge separation --- gas adsorption --- damage evolution --- Unsaturation --- chloride --- concrete --- coupling model --- numerical calculation --- debris flow --- forecasting --- rainfall-unstable soil coupling mechanism(R-USCM) --- scoops3D --- Jiaohe --- non-aqueous phase liquid --- finite element method --- two-phase flow --- mixed-form formulation --- FLAC --- pore structure --- movable fluid --- tight sandstones --- Ordos Basin --- tectonically deformed coal --- coal and gas outburst --- coal-like material --- mechanical properties --- deformation feature --- adsorption/desorption properties --- minerals --- mechanical properties --- uniaxial compressive strength --- crack distribution characteristics --- discrete element method --- lignite --- nitric acid modification --- pore structure --- surface characteristics --- adsorption performance --- n/a

Fluid Flow in Fractured Porous Media

Authors: ---
ISBN: 9783039214730 / 9783039214747 Year: Volume: 2 Pages: 492 DOI: 10.3390/books978-3-03921-474-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

The fluid flow in fracture porous media plays a significant role in the assessment of deep underground reservoirs, such as through CO2 sequestration, enhanced oil recovery, and geothermal energy development. Many methods have been employed—from laboratory experimentation to theoretical analysis and numerical simulations—and allowed for many useful conclusions. This Special Issue aims to report on the current advances related to this topic. This collection of 58 papers represents a wide variety of topics, including on granite permeability investigation, grouting, coal mining, roadway, and concrete, to name but a few. We sincerely hope that the papers published in this Special Issue will be an invaluable resource for our readers.

Keywords

scanning electron microscope (SEM) images --- permeability --- high temperature --- Darcy’s law --- confining pressures --- chemical grouts --- grain size of sand --- initial water contained in sand --- grouted sand --- macroscopic mechanical behaviors --- microstructure characteristics --- ductile failure --- gas concentration --- gob-side entry retaining (GER) --- limestone roof --- roof-cutting resistance --- roadside backfill body (RBB) --- solid backfill coal mining --- goaf --- water soaked height --- loose gangue backfill material --- deformation --- crushing ratio --- fracture grouting --- cement–silicate grout --- geophysical prospecting --- seepage --- Yellow River Embankment --- contiguous seams --- water-dripping roadway --- roadway deformation --- bolt support --- pervious concrete --- permeability coefficient --- porosity --- pore distribution characteristics --- strength --- soil–structure interface --- internal erosion --- critical hydraulic gradient --- orthogonal tests --- Pseudo Steady-State (PPS) constant --- finite-conductivity fracture --- conductivity-influence function --- normalized conductivity-influence function --- circular closed reservoir --- glutenite --- gravel --- hydraulic fracture --- numerical simulation --- propagation --- glauberite cavern for storing oil &amp --- gas --- thermal-hydrological-chemical interactions --- temperature --- brine concentration --- microstructure --- micro-CT --- damage --- cyclic heating and cooling --- physical and mechanical parameters --- failure mode --- acoustic emission --- anisotropy --- bedding plane orientation --- coal --- gas --- adsorption–desorption --- laboratory experiment --- pore pressure --- hydro-mechanical coupling --- fracture closure --- constitutive model --- effective stress --- debris flow --- dynamic characteristics --- numerical analysis --- debris-resisting barriers --- coal measures sandstone --- creep characteristics --- seepage pressure --- seepage-creep --- microscopic morphology --- Darcy flow --- heterogeneity --- numerical manifold method --- high-order --- refraction law --- hydraulic fracture network --- cohesive element method --- coal seams --- fracture propagation --- discontinuous natural fracture --- secondary fracture --- fault water inrush --- coupled THM model --- nonlinear flow in fractured porous media --- numerical model --- warning levels of fault water inrush --- bentonite-sand mixtures --- differential settlement --- deformation --- hydraulic conductivity --- crack --- geogrid --- enhanced permeability --- deviatoric stress --- mechanical behavior transition --- CH4 seepage --- volumetric strain --- strain-based percolation model --- rock-soil mechanics --- soft filling medium --- segmented grouting --- split grouting --- model experiment --- reinforcement mechanism --- longwall mining --- gob behaviors --- stress relief --- permeability --- gas drainage --- hard and thick magmatic rocks --- orthogonal ratio test --- similar simulation --- fracture --- bed separation --- disaster-causing mechanism --- artificial joint rock --- shear-flow coupled test --- hydraulic aperture --- roughness --- seepage pressure --- mixing --- conservative solute --- fractal --- roughness --- fracture --- transversely isotropic rocks --- failure mechanism --- particle flow modeling --- interface --- n/a --- fractured porous rock mass --- grouting experiment --- visualization system --- flow law --- layered progressive grouting --- sandstone and mudstone particles --- rheological deformation --- segmented rheological model --- rheological limit strain --- rheological test --- water-rock interaction --- dry-wet cycles --- slope stability --- laboratory experiment --- mechanical properties --- Xinjiang --- land reclamation --- management period --- soil particle size --- fluid flow in reclaimed soil --- effluents --- soil properties --- cohesive soils --- contamination --- time variation --- stabilization --- mixer --- viscoelastic fluid --- pore structure --- orthogonal test --- fluid–solid coupling theory --- similar-material --- regression equation --- optimum proportioning --- hydraulic fracturing --- gas fracturing --- oriented perforation --- fracture propagation --- damage mechanics --- fluid viscosity --- CO2 flooding --- supercritical CO2 --- CO2 geological storage --- tight sandstone gas reservoirs --- enhanced gas recovery --- flotation --- coal particle --- collision angle --- initial settlement position --- particle velocity --- adhesion efficiency --- green mining --- paste-like slurry --- XRD --- intelligent torque rheometer --- on-site monitoring --- cyclic wetting-drying --- deterioration --- sandstone --- mudstone --- elastic modulus --- uniaxial compressive strength --- permeability characteristics --- grading broken gangue --- compressive stress --- compression deformation --- mine shaft --- alternate strata --- surrounding rock --- shaft lining --- relief excavation --- consolidation process --- unsaturated soil --- semi-analytical solution --- impeded drainage boundary --- excess pore-pressures --- coalbed methane (CBM) --- soft coal masses --- pore structure --- fractal pore characteristics --- hydraulic fractures --- PPCZ --- multitude parameters --- propagation pattern --- stress interference --- naturally fracture --- filtration effects --- grout penetration --- unified pipe-network method --- two-phase flow --- fractured porous medium --- new cementitious material --- cement-based paste discharge --- XRD --- TG/DTG --- SEM --- MIP --- mechanical behaviors --- rock fracture --- shear-flow coupled test --- constant normal stiffness conditions --- transmissivity --- hydraulic aperture --- water inrush prevention --- backfill mining --- strata movement --- ground pressure --- floor failure depth --- water–rock interaction --- degradation mechanism --- mixed mode fracture resistance --- fracture criteria --- T-stress --- hydro-power --- high-steep slope --- fractured rock --- permeability --- seepage control --- gas-bearing coal --- electrical potential --- charge separation --- gas adsorption --- damage evolution --- Unsaturation --- chloride --- concrete --- coupling model --- numerical calculation --- debris flow --- forecasting --- rainfall-unstable soil coupling mechanism(R-USCM) --- scoops3D --- Jiaohe --- non-aqueous phase liquid --- finite element method --- two-phase flow --- mixed-form formulation --- FLAC --- pore structure --- movable fluid --- tight sandstones --- Ordos Basin --- tectonically deformed coal --- coal and gas outburst --- coal-like material --- mechanical properties --- deformation feature --- adsorption/desorption properties --- minerals --- mechanical properties --- uniaxial compressive strength --- crack distribution characteristics --- discrete element method --- lignite --- nitric acid modification --- pore structure --- surface characteristics --- adsorption performance --- n/a

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eng (4)


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2019 (4)