Search results: Found 6

Listing 1 - 6 of 6
Sort by
Cadmium Sources and Toxicity

Author:
ISBN: 9783038979845 9783038979852 Year: Pages: 130 DOI: 10.3390/books978-3-03897-985-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-06-26 08:44:06
License:

Loading...
Export citation

Choose an application

Abstract

Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent. In this collection, environmental Cd exposure is linked to an increased risk of chronic kidney disease that is known to be a cause of morbidity and mortality worldwide. Cd is also implicated in an early onset of menarche and deaths from cancer, especially in the uterus, kidney, and urinary tract. Moreover, Cd-induced kidney injury is replicated in Sprague Dawley rats, as is Cd-induced periodontal disease. Experimental studies suggest that the development of kidneys in fetuses and the function of insulin-producing cells may be adversely affected by Cd and that metformin, an anti-diabetic drug, is ineffective in Cd-intoxicated Wistar rats.

Mass Spectrometric Proteomics

Author:
ISBN: 9783038978268 9783038978275 Year: Pages: 192 DOI: 10.3390/books978-3-03897-827-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-04-25 16:37:17
License:

Loading...
Export citation

Choose an application

Abstract

As suggested by the title of this Special Issue, liquid chromatography-mass spectrometry plays a pivotal role in the field of proteomics. Indeed, the research and review articles  published in the Issue clearly evidence how the data produced by this sophisticated methodology may promote impressive advancements in this area. From among the topics discussed in the Issue, a few point to the development of  new procedures for the  optimization of the experimental conditions that should be applied  for the identification of proteins present in complex mixtures.  Other applications  described in these articles show  the huge potential of  these strategies in the protein profiling of organs and  range from  to the study of post-translational tissue modifications to the investigation of the molecular mechanisms behind human disorders and the identification of potential biomarkers of these diseases.

Modern Sample Preparation Approaches for Separation Science

Author:
ISBN: 9783039214112 9783039214129 Year: Pages: 282 DOI: 10.3390/books978-3-03921-412-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

This book will provide the most recent knowledge and advances in Sample Preparation Techniques for Separation Science. Everyone working in a laboratory must be familiar with the basis of these technologies, and they often involve elaborate and time-consuming procedures that can take up to 80% of the total analysis time. Sample preparation is an essential step in most of the analytical methods for environmental and biomedical analysis, since the target analytes are often not detected in their in-situ forms, or the results are distorted by interfering species. In the past decade, modern sample preparation techniques have aimed to comply with green analytical chemistry principles, leading to simplification, miniaturization, easy manipulation of the analytical devices, low costs, strong reduction or absence of toxic organic solvents, as well as low sample volume requirements.Modern Sample Preparation Approaches for Separation Science also provides an invaluable reference tool for analytical chemists in the chemical, biological, pharmaceutical, environmental, and forensic sciences.

Keywords

vitamins --- extraction --- determination --- review --- sample preparation --- matrix solid phase dispersion --- sorbent --- miniaturization --- on-line --- blueberry --- non-anthocyanin polyphenol --- vortex-assisted dispersive liquid-liquid microextraction --- response surface methodology --- desirability function approach --- nail --- curie temperature --- high-frequency heating --- liquid chromatography–tandem mass spectrometry --- caffeine --- amlodipine --- gas chromatography --- hydrogel --- hormones --- pectin --- polyvinyl alcohol --- sample preparation --- in-tube SPME --- UHPLC-MS/MS --- organic-based monoliths --- antipsychotics --- plasma samples --- schizophrenic’ patients --- salting-out assisted liquid–liquid extraction --- sugaring-out assisted liquid–liquid extraction --- hydrophobic-solvent assisted liquid–liquid extraction --- subzero-temperature assisted liquid–liquid extraction --- phenolic compounds --- sorbent-based techniques --- multi-spheres adsorptive micro-extraction (MSA?E) --- floating sampling technology --- caffeine and acetaminophen tracers --- environmental water matrices --- vortex-assisted dispersive liquid-liquid microextraction --- China herbal tea --- pesticides residue --- aflatoxins --- UPLC-MS/MS --- vortex-synchronized matrix solid-phase dispersion --- crab shells --- ionic liquids --- anthraquinones --- Cassiae Semen --- sample preparation --- nanocomposite --- pathogenic --- enrichment --- nucleic acid isolation --- sample preparation with TLC/HPTLC --- solvent front position extraction --- solvent delivery with a moving pipette --- automation --- LC–MS/MS --- environmental analysis --- whole water --- trace analysis --- SPE --- large volume --- in-line filter --- sand --- flow rate --- pharmaceuticals --- hormones --- pesticides --- space instrumentation --- liquid chromatography --- oligopeptides --- trapping system --- membrane-based microextraction --- barbiturates --- simultaneous determination --- whole blood --- urine --- liver --- sample preparation --- oxylipins --- protein precipitation --- liquid–liquid extraction --- solid-phase extraction --- biological samples --- chlorophenoxy acid herbicides --- HPLC --- hydrophobic in-tube solid-phase microextraction --- poly (OMA-co-TRIM) monolithic column --- rice grains --- gold --- sample preparation --- preconcentration --- geological samples

Cocoa, Chocolate and Human Health

Authors: ---
ISBN: 9783039285884 / 9783039285891 Year: Pages: 288 DOI: 10.3390/books978-3-03928-589-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

This book entitled “Cocoa, Chocolate, and Human Health” presents the most recent findings about cocoa and health in 14 peer-reviewed chapters including nine original contributions and five reviews from cocoa experts around the world. Bioavailability and metabolism of the main cocoa polyphenols, i.e., the flavanols like epicatechin, are presented including metabolites like valerolactones that are formed by the gut microbiome. Many studies, including intervention studies or epidemiological observations, do not focus on single compounds, but on cocoa as a whole. This proves the effectiveness of cocoa as a functional food. A positive influence of cocoa on hearing problems, exercise performance, and metabolic syndrome is discussed with mixed results; the results about exercise performance are contradictive. Evidence shows that cocoa flavanols may modulate some risk factors related to metabolic syndrome such as hypertension and disorders in glucose and lipid metabolism. However, several cardiometabolic parameters in type 2 diabetics were not affected by a flavanol-rich cocoa powder as simultaneous treatment with pharmaceuticals might have negated the effect of cocoa. The putative health-promoting components of cocoa are altered during processing like fermentation, drying, and roasting of cocoa beans. Chocolate, the most popular cocoa product, shows remarkable losses in polyphenols and vitamin E during 18 months of storage.

Keywords

type 2 diabetes --- flavanol-rich cocoa --- blood pressure --- glucose metabolism --- lipid status --- type 2 diabetes --- flavanol-rich cocoa --- postprandial --- meal --- glucose metabolism --- lipids --- blood pressure --- cocoa processing --- cocoa proteins --- classification --- extraction and characterization methods --- fermentation-related enzymes --- bioactive peptides --- heath potentials --- protein–phenol interactions --- chocolate --- hearing loss --- tinnitus --- cohort study --- cocoa --- bioactive compounds --- flavanols bioavailability --- anti-inflammatory properties --- metabolic syndrome --- oxidative stress --- cocoa by-product --- functional food --- polyphenols --- ?-glucosidase inhibition --- antidiabetic capacity --- antioxidant capacity --- methylxanthines --- fermentation --- functional volatile compounds --- starter culture --- yeast --- roasting --- chocolate --- cocoa beans --- theobromine --- cacao --- working memory --- behavior --- CaMKII --- CREB --- BDNF --- cocoa --- oligopeptides --- simulated gastrointestinal digestion --- angiotensin-converting enzyme (ACE) inhibitory activity --- cocoa --- chocolate --- metabolites --- biomarkers --- metabolomics --- urine --- plasma --- procyanidins --- methylxanthines --- polyphenols --- flavanols --- soluble cocoa products --- bioavailability --- human --- plasma nutrikinetics --- liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (LC-ESI-QToF-MS) --- colonic bacteria --- athlete --- cocoa --- chocolate --- exercise performance --- oxidative stress --- performance --- physical exercise --- polyphenol --- skeletal muscle --- inflammation --- Italian chocolate --- quality --- cocoa-based ingredients --- monitoring --- nutrition --- cocoa --- flavan-3-ol stereoisomers --- (?)-epicatechin --- (+)-catechin --- (?)-catechin --- plasma appearance --- chiral separation --- pharmacokinetics --- one-compartment model --- n/a

Gluten-Free Diet

Author:
ISBN: 9783038977360 9783038977377 Year: Pages: 318 DOI: 10.3390/books978-3-03897-737-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-04-25 16:37:17
License:

Loading...
Export citation

Choose an application

Abstract

In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.

Keywords

Celiac Disease --- depression --- gluten-free diet --- dietary adherence --- gluten --- gastric emptying --- cholecyst --- celiac disease --- non celiac gluten sensitivity --- gluten-free diet --- gastrointestinal symptoms --- quality of life --- Brazilian CD-QoL --- quality of life --- celiac disease --- questionnaire --- coeliac disease --- celiac disease --- gluten --- gluten-free diet --- fortification --- micronutrient --- cost --- celiac disease --- diagnosis --- gliadin --- gluten --- glutenin --- non-celiac gluten sensitivity --- oral food challenge --- pepsin --- wheat allergy --- celiac disease (CD) --- quality of life (QoL) --- gluten-free diet --- disease duration --- place of residence --- educational level --- economic status --- body mass index (BMI) --- celiac disease --- gluten-free diet --- gut microbiota --- gluten-free diet --- celiac disease --- children --- teenagers --- gluten-related disorders --- celiac disease --- gut microbiota --- gluten-free diet --- Pseudomonas --- gluten-free diet --- mineral --- deficiency --- calcium --- iron --- magnesium --- zinc --- celiac disease --- non-celiac gluten sensitivity --- gut motility --- gluten-free diet --- gluten-related disorders --- gluten-free diet --- coeliac disease --- non-coeliac gluten sensitivity --- irritable bowel syndrome --- mood disorders --- affective disorders --- depression --- major depressive disorder --- mental health --- nutrition --- celiac disease --- gluten-free diet --- diary recommended intake --- food habit --- body composition --- non-coeliac gluten sensitivity --- gluten --- wheat --- low FODMAP diet --- irritable bowel syndrome --- beta cell --- beta-cell stress --- celiac disease --- gluten-free diet --- high-fat diet-induced obesity --- intestinal permeability --- islet of Langerhans --- NOD mouse --- type 1 diabetes --- type 2 diabetes --- FODMAP intake --- celiac disease --- irritable bowel syndrome --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- gluten-free diet --- effectiveness --- adherence --- nutritionists --- clinic --- serology --- duodenal biopsies --- structured questionnaires --- peptides derived from gluten in faeces and urine --- gluten --- adherence --- serology --- villous atrophy --- mucosal recovery --- threshold --- celiac disease --- body composition --- gluten free diet --- children --- celiac disease --- gluten --- gluten-free diet --- screening --- outcome --- gluten sensitivity --- osteoporosis --- non-celiac gluten sensitivity --- gluten re-introduction --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- ?-gliadin --- 33-mer --- DQ2.5-glia-?1 --- DQ2.5-glia-?2 --- DQ2.5-glia-?3 epitopes --- wheat species --- n/a --- gluten --- gluten-free diet --- coeliac disease --- non-celiac gluten sensitivity --- non-coeliac wheat sensitivity --- gliadin --- microbiota

Renal Cell Carcinoma

Author:
ISBN: 9783039286386 / 9783039286393 Year: Pages: 500 DOI: 10.3390/books978-3-03928-639-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

Renal cancer is a health problem of major concern worldwide. Although tyrosine kinase inhibitors and immune check-point blockade treatments, alone or in combination, are giving promising results, failures are quite frequent due to intratumor heterogeneity and to the acquisition of drug resistance. The spectrum of renal cell carcinoma subtypes is wide. Up to 70–80% of renal tumors are clear cell renal cell carcinomas, a clinically aggressive tumor subtype linked to VHL gene inactivation. Next in frequency, the papillary renal cell carcinoma category encompasses an intricate puzzle of classic and newly described entities with poorly defined limits, some of them pending definite clarification. Likewise, the chromophobe–oncocytoma duality, the so-called hybrid tumors and oncocytic neoplasms, remain to be well profiled. Finally, a growing list of very uncommon renal tumors linked to specific molecular signatures fulfill the current portrait of renal cell neoplasia. This Special Issue of Cancers regards RCC from very different perspectives, from the intimate basic mechanisms governing this disease to the clinical practice principles of their diagnoses and treatments. The interested reader will have the opportunity to contact with some of the most recent findings and will be updated with excellent reviews.

Keywords

ghrelin --- aurora A --- MMP10 --- invasion --- sarcomatoid --- RCC --- immunotherapy --- checkpoint inhibitors --- survival --- PD-L1 --- chronic kidney disease --- nephrectomy --- overall survival --- recurrence free survival --- renal cell carcinoma --- statins --- uric acid --- intratumour heterogeneity --- metastatic ccRCC --- copy number alteration --- mutation --- gene expression --- MiT family translocation renal cell carcinoma --- Xp11 translocation renal cell carcinoma --- t(6 --- 11) translocation renal cell carcinoma --- FISH --- TFE3 --- TFEB --- TFEB-amplified renal cell carcinoma --- renal cell carcinoma --- immune checkpoint inhibitors --- tyrosine kinase inhibitors --- efficacy --- toxicity --- cytoreductive nephrectomy --- Papillary renal cell carcinoma (pRCC) --- proteome profiling --- metabolome profiling --- glutathione metabolism --- metabolic reprogramming --- IL4R? --- IL13R?1 --- renal cell carcinoma --- JAK2 --- FOXO3 --- clear cell renal cell carcinoma --- identification of circular RNAs --- experimental validation of circular RNA --- diagnostic and prognostic markers --- circular RNAs in a clinico-genomic predictive model --- cancer-specific survival --- recurrence-free survival --- overall survival --- chromophobe renal cell carcinoma --- pale cell --- eosinophilic variant --- chromosomal loss --- copy number analysis --- renal cell carcinoma --- clear cell renal cell carcinoma --- AMP-activated protein kinases --- immunohistochemistry --- prognosis --- SMAD proteins --- transforming growth factor beta --- renal cell cancer --- microRNA --- metabolome --- proliferation --- PPP --- pentose phosphate pathway --- TCA cycle --- miR-155-5p --- miR-146a-5p --- TCGA --- renal cell carcinoma --- metastasis --- MTA2 --- MMP-9 --- miR-133b --- kidney cancer --- immunotherapy --- renal cell --- inflammation markers --- programmed death-ligand 1 --- immune checkpoint inhibitors --- prognostic factors --- predictive factors --- glutathione transferase omega 1 --- glutathione transferase omega 2 --- polymorphism --- PI3K/Akt/mTOR --- Raf/MEK/ERK --- IL-1? --- pro-IL-1? --- gene signature --- renal cancer --- survival prediction --- polybromo-1 --- PBRM1 --- renal cell carcinoma --- biomarker --- prognosis --- predictive role --- collecting duct carcinoma --- RNA sequencing --- solute carrier proteins --- kidney --- renal cell carcinoma --- molecular genetic features --- practical approach --- review --- renal cell carcinoma --- sarcomatoid --- immunotherapy --- renal cell carcinoma --- checkpoint inhibitors --- VEGF inhibitors --- mTOR inhibitors --- kidney --- emerging entity --- new entity --- oncocytic renal tumor --- unclassified renal cell carcinoma --- unclassified renal tumor --- anaplastic lymphoma kinase rearrangement --- ALK --- ESC --- HOT --- LOT --- drug sensitivity --- immune infiltration --- renal cancer --- targeted therapy --- tumor slice culture --- clear cell Renal Cell Carcinoma --- urine --- glycoproteomics --- N-glycomapping --- label-free --- glycomarkers --- everolimus --- EVI1 --- genetic association --- mTOR --- clear cell renal cell carcinoma --- curcumin --- renal cell cancer --- tumor adhesion --- tumor migration --- integrins --- NK cells --- kidney cancer --- renal cell carcinoma --- IL-2 --- cancer immunotherapy --- tumor microenvironment --- von Hippel–Lindau --- EMT like --- hyperosmolality --- chromophobe renal cell carcinoma --- copy number loss --- CDKN1A expression --- patient survival --- prognosis --- n/a

Listing 1 - 6 of 6
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (6)


License

CC by-nc-nd (6)


Language

english (4)

eng (2)


Year
From To Submit

2020 (2)

2019 (4)