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Numerical Haemodynamics in the Human Heart

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Book Series: Schriftenreihe des Instituts für Strömungsmechanik, Karlsruher Institut für Technologie ISSN: 21998868 ISBN: 9783731507574 Year: Volume: 3 Pages: VII, 180 p. DOI: 10.5445/KSP/1000080044 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-28 18:37:01
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The characteristic vortex formation in the ventricles is believed to be affected at an early stage of heart diseases. First, post-processing of patient-specific data has to be standardised. The chosen methods, a combination of Eulerian and Lagrangian techniques, are characterised by means of necessary spatial and temporal resolutions. Second, the goal is to find the best cost-benefit approach for modelling of the mitral valve, as it affects vortex formation and progression in the left ventricle.

The Pathogenetic Mechanisms at the Basis of Aortopathy Associated with Bicuspid Aortic Valve: Insights from "Omics", Models of Disease and Emergent Technologies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453955 Year: Pages: 170 DOI: 10.3389/978-2-88945-395-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2018-11-16 17:17:57
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This forum of comprehensive reviews and research studies on distinct aspects of the pathophysiology of BAV aortopathy provides both the state of the art in the knowledge on this complex disease and novel insights into its causes and consequences. The present collection of focused papers also envisions and proposes new therapeutic strategies, novel biomarkers and original risk stratification criteria, for the improvement of patient management.

Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456208 Year: Pages: 118 DOI: 10.3389/978-2-88945-620-8 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General)
Added to DOAB on : 2019-01-23 14:53:43
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It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification.In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.

Entwicklung eines mikrofluidischen Brailledisplays

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Book Series: Schriften des Instituts für Mikrostrukturtechnik am Karlsruher Institut für Technologie / Hrsg.: Institut für Mikrostrukturtechnik ISSN: 18695183 ISBN: 9783731503859 Year: Volume: 32 Pages: XVI, 163 p. DOI: 10.5445/KSP/1000047135 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
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For cost reasons braille displays used by the visually impaired to access digital data through the sense of touch are limited to displaying one line of text. However, by using cost effective microfluidic actuators it is possible to manufacture large-scale braille displays. This work describes the working principle and the manufacturing techniques used for fabricating components of such a display and the results of an online survey revealing the user requirements regarding braille displays.

Advances in Water Distribution Networks

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ISBN: 9783038975564 Year: Pages: 174 DOI: 10.3390/books978-3-03897-557-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Environmental Engineering
Added to DOAB on : 2019-03-08 11:42:05
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The Special Issue on Advances in Water Distribution Networks (WDNs) explores four important topics of research in the framework of WDNs, namely simulation and optimization modelling, topology and partitioning, water quality, and service effectiveness. With regard to the first topic, the following aspects are addressed: pressure-driven formulations, algorithms for the optimal location of control valves to minimize leakage, the benefits of water discharge prediction for the remote real time control of valves, and transients generated by pumps operating as turbines. In the context of the second topic, a topological taxonomy of WDNs is presented, and partitioning methods for the creation of district metered areas are compared. In relation to the third topic, the vulnerability to trihalomethane is assessed, and a statistical optimization model to minimize heavy metal releases is presented. Finally, the fourth topic focusses on the estimation of non-revenue water, including leakage and unauthorized consumption, and on the assessment of service under intermittent supply conditions.

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