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Advances in Hematopoietic Stem Cell Research

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ISBN: 9789533079301 Year: Pages: 478 DOI: 10.5772/1203 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:48

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This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.

The Amygdala - Where Emotions Shape Perception, Learning and Memories

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ISBN: 9789535132493 9789535132509 Year: Pages: 336 DOI: 10.5772/63124 Language: English
Publisher: IntechOpen
Subject: Physiology --- Cytology
Added to DOAB on : 2019-10-03 07:51:50

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The amygdala is a central component of the limbic system, which is known to play a critical role in emotional processing of learning and memory. Over these last 20 years, major advances in techniques for examining brain activity greatly helped the scientific community to determine the nature of the contribution of the amygdala to these fundamental aspects of cognition. Combined with new conceptual breakthroughs, research data obtained in animals and humans have also provided major insights into our understanding of the processes by which amygdala dysfunction contributes to various brain disorders, such as autism or Alzheimer's disease. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in the mechanisms underlying emotional learning and memory, we hope it will also help stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.

Autophagy in Current Trends in Cellular Physiology and Pathology

Authors: ---
ISBN: 9789535127260 9789535127277 9789535141525 Year: Pages: 526 DOI: 10.5772/61911 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:49

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Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Calcium and Signal Transduction

Authors: ---
Book Series: Physiology ISSN: 26318261 ISBN: 9781789842494 9781789842500 Year: Volume: 1 Pages: 202 DOI: 10.5772/intechopen.74489 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Since the development of microelectronic clamping methodology and fluorescent indicators for direct measurement of dynamic intracellular calcium transients, our understanding of biological signal transduction has progressed dramatically since the 1980s. Calcium is a universal signal in biology that modulates gene expression, transmitter and hormone release, muscular movement, and even ""programmed"" cell death. This book represents a compilation of chapters from a diverse set of expert biologists throughout the world who have conducted research in the general area of calcium signaling in organisms ranging from bacteria to humans. In accord with priorities of resolving human disease, the reader will also benefit from learning calcium's role in cellular signaling pathology relating to acute or chronic conditions such as vomiting, sepsis, obesity, hypertension, and cancer.

Cell Culture

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ISBN: 9781789848663 9781789848670 Year: Pages: 292 DOI: 10.5772/intechopen.73709 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:52

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Cell culture is one of the major tools used in cellular and molecular biology, delivering an excellent model for studying the normal physiology and biochemistry of cells. This book covers some advanced aspects in cell culture methodologies. The book has four sections discussing different types of cell culture models, including 3D cell culture techniques, their advantages, and limitations in comparison to traditional 2D culturing; cell viability, autophagy, in vitro toxicity tests and live cell imaging; stem cell culture for cell-based therapeutics; and specific applications and methodologies for hybrid cell lines and cancer models. This book provides a comprehensive overview of some of the advanced cell culture methodologies and applications. It serves as a valuable source for scientists, researchers, clinicians and students.

Cell Death - Autophagy, Apoptosis and Necrosis

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ISBN: 9789535122364 9789535142119 Year: Pages: 446 DOI: 10.5772/59648 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:49

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This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Cell Signalling - Thermodynamics and Molecular Control

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ISBN: 9781838800659 9781838800666 Year: Pages: 84 DOI: 10.5772/intechopen.73411 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:53

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Intracellular signal transduction is an important topic of research in cell and molecular biology. It has a wide range of implications in growth, differentiation, development, animal polarity, cellular response monitoring, and many disease processes, including cancer. The functional homeostasis of a cell is assumed to be maintained by an intricate network of signaling that evolved through natural selection. This book includes chapters written in the frontier areas of research on cell signaling. Issues such as information thermodynamics, master regulation of immune tolerance, genetically encoded reporter circuits and their applications, hypoxia, and vitamin K2 mediated signaling processes are addressed and discussed by eminent researchers of the field.

Cryopreservation in Eukaryotes

Authors: ---
ISBN: 9789535127796 9789535127802 9789535141433 Year: Pages: 228 DOI: 10.5772/62605 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:49

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Since accidentally discovering the ability of glycerol on protecting cells from freezing damage, many researchers have been pursuing to develop cryopreservation methods of a very wide range of cells and some tissues, and these have found widespread applications in biology and medicine. From the point of view of living organisms, cryopreservation is a useful tool for ex situ conservation of genetic resources together with its contribution on conservation of their biodiversity. Cryopreservation in Eukaryotes includes totally 12 chapters, which have been written by the expert researchers in the field. The chapters are a comprehensive collection of the most frequently used methods for eukaryotes. With this book, every researcher will better understand the principles, background, and current status of cryopreservation in particular organisms.

Current Understanding of Apoptosis - Programmed Cell Death

Authors:
ISBN: 9781789235005 9781789235012 Year: Pages: 160 DOI: 10.5772/intechopen.71637 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:51

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Apoptosis is an essential biochemical process in cell turnover, development, and chemical-induced cell death. Current knowledge and ongoing research of apoptosis highlight our understanding in designing the therapeutic approaches for several diseases. This book covers four main sections: ""Apoptosis and Necrosis,"" ""Apoptosis Inducers,"" ""Proteasome and Signaling Pathways in Apoptosis,"" and ""Radiation-Based Apoptosis."" The first section implicitly describes the differences between apoptosis and necrosis processes. The following section elaborates the small molecule-induced apoptosis. Then, the third section deals with proteasome and signaling pathways and finally, resistance to chemotherapy and electromagnetic radiation is covered in the last section. Overall, the book deals with pathways for manipulating apoptosis and provides a unique perspective to the scientists.

Cytoskeleton - Structure, Dynamics, Function and Disease

Authors:
ISBN: 9789535131694 9789535131700 Year: Pages: 342 DOI: 10.5772/62622 Language: English
Publisher: IntechOpen
Subject: Cytology
Added to DOAB on : 2019-10-03 07:51:50

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The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with ""motility"" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

Listing 1 - 10 of 25 << page
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